Curr Med Res Opin. 2001;17(1s) 

In This Article


Buclizine is a piperazine derivative with antihistamine properties. It is commonly combined with paracetamol and codeine as a treatment for migraine widely available without prescription, although efficacy data are limited. A double-blind, randomized crossover trial of 34 patients of oral buclizine 12.5 mg combined with paracetamol 1 g and codeine 16 mg (Migraleve.) confirmed efficacy over placebo[26]. A single dose of this combination is recommended at the onset of migraine followed by subsequent doses of paracetamol and codeine. Buclizine is generally well tolerated but like all antihistamines, sedation is most common. Anticholinergic effects of dry mouth and palpitations can also occur. Contraindications are few and include previous sensitivity. Caution is indicated for patients with a history of renal disease.

Other antihistamines including cinnarizine, cyclizine and promethazine have been used for control of nausea but their efficacy in migraine has not been established.


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