Control of Emesis
There are several different sites of action of antiemetics (Figure 1).
Dopamine antagonists suppress pro-emetic stimuli by blocking D2 receptors in the chemoreceptor trigger zone (CTZ).
5-HT3 antagonists have been more recently developed to block the nausea and vomiting reflexes mediated by stimulation of 5-HT3 receptors in both the small intestine and the CTZ.
Antihistamines, although widely used for migraine, are generally recommended for motion sickness as they act at the level of the vestibular apparatus.
Anticholinergic agents such as atropine and hyoscine are relatively ineffective in the treatment of prevention of vomiting due to causes other than motion and will not be discussed further.
Curr Med Res Opin. 2001;17(1s) © 2001 Librapharm Limited
Cite this: Anti-emetics - Medscape - Dec 01, 2001.