Curr Med Res Opin. 2001;17(1s) 

In This Article

Summary and Introduction


Nausea and vomiting are common symptoms of migraine, which can be controlled with a variety of anti-emetics including phenothiazines and antihistamines. Metoclopramide and domperidone have an additional prokinetic effect which may be important in migraine to overcome gastric stasis and enhance absorption of oral medication.


Nausea and vomiting are common symptoms of migraine. For some individuals these symptoms can be far more distressing and difficult to control than the headache itself. Several anti-emetics are commonly used although clinical trial data are limited. The recognition that gastric stasis accompanies migraine led to trials with gastroprokinetic agents metoclopramide and domperidone, which may have the additional advantage of enhancing the bioavailability of concomitant drugs given orally to treat migraine. Several anti-emetics have also been used as single-agent therapies in migraine with varying success.


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