2001 Annual Meeting of the North American Association for the Study of Obesity

Gary D. Foster, PhD


January 22, 2002

In This Article

Look AHEAD Study

Dr. Donna Ryan,[3] of Louisiana State University provided an overview of the Look AHEAD (Action for Health in Diabetes) Trial, the first research study to examine the long-term effects of intentional weight loss on cardiovascular (CV) outcomes. Currently, there are considerable data demonstrating the positive short-term (1 year) effects of weight loss on CV risk factors such as blood pressure, serum lipids, and glycemic control. However, there is little information on whether these short-term reductions in risk factors affect long-term CV outcomes such as stroke, myocardial infarction, and overall mortality. To that end, Look AHEAD will randomize 5000 overweight patients with type 2 diabetics from 16 centers across the country to either the Diabetes Support and Education Program or the Lifestyle Program. Those in the Diabetes Support and Education Program will be encouraged to attend education sessions on diabetes management, nutrition, and exercise. Those randomized to the Lifestyle Program will attend weekly group sessions for 6 months that focus on acquiring the behavioral skills necessary for weight loss, and biweekly group sessions for an additional 6 months focusing on how to maintain the weight loss. These sessions will continue on a monthly basis for an additional 3 years. The Figure shows the location of the Look AHEAD sites around the country. Enrollment began in October 2001 and will continue for the next 3 years. Additional information can be found on the Look AHEAD Web site at www.lookaheadstudy.org.

Figure. Look AHEAD sites.


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