Agents Interfering With Home Testing of Blood Glucose

John B. Buse, MD, PhD


September 25, 2001


Which drugs and nutritional supplements can interfere with home testing of blood glucose with a glucose meter?

Julio Garcia, MD

Response from John B. Buse, MD, PhD

There is a theoretical concern regarding a variety of substances interfering with glucose-monitoring technology, such as vitamin C. However, for most meters and most strips these issues have been evaluated fairly well, and in general, there does not seem to be a major concern. That said, there is certainly the possibility that some prescription medications and over-the-counter products may interfere with a particular meter or strip and that this interaction may go unrecognized. Furthermore, massively high doses of a compound may produce previously unknown interference because studies to evaluate an interaction were performed at lower doses of the agent.

If you suspect that a particular compound is interfering with glucose testing, I recommend contacting the manufacturer of the glucose-monitoring product in question.

It may be worth noting in this context that if some glucose test strips are used to test a sample taken from a tube containing sodium fluoride, a falsely low value can be obtained. To my knowledge, there is no interference associated with fluoridation of water and either fluoride supplementation or treatment.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: