Oseltamivir: A New Option for the Management of Influenza in Children

Marcia L. Buck, Pharm.D., FCCP

Pediatr Pharm. 2001;7(2) 

In This Article

Mechanism of Action

Oseltamivir phosphate is an oral prodrug which undergoes hydrolysis by hepatic esterases to form active oseltamivir carboxylate, also referred to as GS4071. Oseltamivir carboxylate acts by selective inhibition of influenza A and B viral neuraminidase. A lipophilic side chain of the active drug binds to the virus enzyme, blocking its ability to cleave sialic acid residues on the surface of the infected cell and resulting in an inability to release progeny virions.[4,5,7,8]


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