Clostridium difficile

Lori Hamm, PharmD

Pediatr Pharm. 2000;6(6) 

In This Article


Clostridium difficile, a common gram-positive, spore-forming, anaerobic bacillus, is the leading cause of nosocomial diarrhea associated with antibiotic therapy. Clostridium difficile causes a variety of diarrheal syndromes, including C difficile diarrhea, C difficile colitis, antibiotic-associated C difficile colitis, and pseudomembranous colitis, all of which vary widely in severity. Pseudomembranous colitis is an inflammation of the colon characterized by the presence of elevated lesions, or pseudomembranes, on the mucosal surface. Clostridium difficile is responsible for virtually all cases of pseudomembranous colitis.[1,2,3,4,5] This brief review will focus on the pathophysiology, diagnosis, treatment, and prevention of C difficile infections.


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