Importance of Postprandial Glucose Control

, Department of Medicine, University of Alabama at Birmingham School of Medicine

South Med J. 2001;94(8) 

In This Article

Keypoints

  • Modulation of postprandial plasma glucose plays an important role in overall glycemic control.

  • There is a strong correlation between high postprandial glu- cose level and the development of vascular complications.

  • First phase insulin release is lost early in the development of type 2 diabetes, leading to postprandial hyperglycemia, increased insulin resistance, and decreased insulin production.

  • With loss of the first phase insulin release, an exaggerated second phase insulin release in response to the postprandial hyperglycemia can cause postprandial hypoglycemia.

  • Emerging drugs that reduce postprandial hyperglycemia in- clude nateglinide, pramlitide,and glucagon-like insulin-otropic peptide.

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