Modulation of postprandial plasma glucose plays an important role in overall glycemic control.
There is a strong correlation between high postprandial glu- cose level and the development of vascular complications.
First phase insulin release is lost early in the development of type 2 diabetes, leading to postprandial hyperglycemia, increased insulin resistance, and decreased insulin production.
With loss of the first phase insulin release, an exaggerated second phase insulin release in response to the postprandial hyperglycemia can cause postprandial hypoglycemia.
Emerging drugs that reduce postprandial hyperglycemia in- clude nateglinide, pramlitide,and glucagon-like insulin-otropic peptide.
Reprint requests to David S. Bell, MB, University of Alabama at Birmingham, Department of Medicine, 1808 7th Ave S, Room 813, Birmingham, AL 35294.
South Med J. 2001;94(8) © 2001 Lippincott Williams & Wilkins
Cite this: Importance of Postprandial Glucose Control - Medscape - Aug 01, 2001.