Successful Use of Cyclooxygenase-2 Inhibitor in a Patient With Aspirin-Induced Asthma

Fred Marks, MD, Piedmont Health Care, Statesville, NC; Kristopher Harrell, PharmD, Rick Fischer, PharmD, Department of Clinical Pharmacy Practice, University of Mississippi Medical Center, Jackson

South Med J. 2001;94(2) 

In This Article


Patients with AIA have limited alternatives for use of medications in inflammatory processes. There is no evidence of immunologic cross-reactivity as the cause of AIA, but instead evidence implicates inhibition of COX as the initiating event. Successful use of COX-2 inhibitors in AIA patients also suggests that inhibition of COX-1 and the subsequent decrease in prostaglandins and increase in leukotrienes are likely causes. Cyclooxygenase-2 inhibitors, despite contraindications in the package information of their manufacturers, may be safe alternatives for AIA patients who require anti-inflammatory medications.


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