Quinolones and Tendon Ruptures

Conclusion

Fluoroquinolone-associated tendon disruption, including rupture, is well described in the literature. Although the Achilles tendon is the most susceptible site, other tendons may be affected. Typically, spontaneous tendon rupture occurs during or shortly after a course of therapy, but symptoms may occur months after taking fluoroquinolones. Whether fluoroquinolones should be used in patients with a history of tendon problems or with risk factors for the development of tendon ruptures depends on the seriousness of the infection and the alternatives available. Awareness of the association between tendon disorders and fluoroquinolones may lead to enhanced surveillance, which should be extended to sites beyond the Achilles tendon and to periods of months after a course of these antibiotics.

South Med J. 2000;93(5) © 2000  Lippincott Williams & Wilkins

Cite this: Quinolones and Tendon Ruptures - Medscape - May 01, 2000.