Julio M. Pow-Sang, MD, Genitourinary Oncology Program at the H. Lee Moffitt Cancer Center & Research Institute, Tampa, Fla.

Cancer Control. 2001;8(2) 

Introduction

  • Babaian RJ, Johnston DA, Naccarato W, et al. The incidence of prostate cancer in a screening population with a serum prostate specific antigen between 2.5 and 4.0 ng/mL: relation to biopsy strategy. J Urol. 2001;165:757-760.
    A significant incidence of cancer (24.5%) was found in men with a serum PSA between 2.5 and 4.0 ng/mL; 67.6% of the cancers were significant.

  • Gao B, Shen X, Kunos, G, et al. Constitutive activation of JAKSTAT3 signaling by BRCA1 in human prostate cancer cells. FEBS Lett. 2001;488:179-184.
    BRCA1 interacts with the components of the JAK-STAT signaling cascade and modulates its activation. This interaction may provide a new critical survival signal for the growth of prostate cancer in the presence of normal BRCA1.

  • Junicho A, Matsuda T,Yamamoto T, et al. Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells. Biochem Biophys Res Commun. 2000;278:9-13.
    The protein inhibitor of activated STAT3 (PIAS3) acts as a coregulator of androgen receptor signaling pathway in prostate cancer cells.

  • Signoretti S, Montironi R, Manola J, et al. Her-2-neu expression and progression toward androgen independence in human prostate cancer. J Natl Cancer Inst. 2000;92:1918-1925.
    Her-2-neu expression appears to increase with progression to androgen independence in prostate cancer. Therapeutic targeting of this tyrosine kinase in prostate cancer may be warranted.

  • Katz G, Rodriguez R. Use of a modified American Urological Association Symptom Score for the evaluation of the quality of life of patients with prostate cancer. Urology. 2001;57:112-116.
    The questionnaire provides insight into the quality of life and symptoms associated with curative interventions and enhances the objective documentation of treatment outcomes in prostate cancer.

  • Rubin MA, Mucci NR, Manley S, et al. Predictors of Gleason pattern 4/5 prostate cancer on prostatectomy specimens: can high grade tumor be predicted preoperatively? J Urol. 2001;165:114-118.
    Biopsy parameters such as Gleason pattern 4/5 may provide adequate specificity for predicting clinically significant cancers. The accuracy of these parameters for predicting indolent cancer is limited by the unacceptable high rate of false-negative findings.

  • D'Amico AV, Schultz D, Silver B, et al. The clinical utility of the percent of positive prostate biopsies in predicting biochemical out-come following external-beam radiation therapy for patients with clinically localized prostate cancer. Int J Radiat Oncol Biol Phys. 2001;49:679-684.
    The percent positive prostate biopsies should be considered in conjunction with the PSA level, biopsy Gleason score, and clinical T stage when counseling patients with newly diagnosed and clinically localized prostate cancer about PSA outcome following radical prostatectomy or external-beam radiation therapy.

  • Oh W, George D, Hackmann K, et al. Activity of the herbal combination, PC-SPES, in the treatment of patients with androgen-independent prostate cancer. Urology. 2001;57:122-126.
    PC-SPES is well tolerated and active in androgen-independent prostate cancer.

  • Colletier PJ, Ashoori F, Cowen D, et al. Adenoviral-mediated p53 transgene expression sensitizes both wild-type and null p53 prostate cancer cells in vitro to radiation. Int J Radiat Oncol Biol Phys. 2000;48:1507-1512.
    p53 transgene expression sensitizes human prostate adenocarcinoma cells in vitro to irradiation.

  • Han M, Snow P, Epstein J, et al. A neural network predicts progression for men with Gleason score 3+4 versus 4+3 tumors after radical prostatectomy. Urology. 2000;56: 994-999.
    A modification of the Gleason scoring system for men with Gleason 7 disease revealed a difference in outcome after radical prostatectomy. Artificial neural network models can be developed and used to better predict patient outcome when pathologic and clinical features are known.

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