Therapeutic Role of Nitric Oxide in Respiratory Disease

Thomas E. Siddons, BSc, Mohammed Asif, MA, BMBCh, FRCS, and Tim W. Higenbottam, MD, MA, BSc, FRCP, University of Sheffield, Sheffield, United Kingdom

In This Article


Inhaled NO therapy is an effective form of treatment in acute conditions, such as ARDS and PPHN; it is particularly effective in increasing oxygen saturation and decreasing pulmonary artery pressure. It also seems to be effective in chronic disorders, such as COPD and pulmonary hypertension. Whether NO therapy has a significant effect on survival is still being debated and will continue to be until the results of long-term, large-scale trials are evaluated.


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