Johannes D. Veldhuis, MD


March 15, 2000

In This Article

Role of the Endocrine System in the Biologic Variability of Aging

The remarkable variability in the physical status of the healthy-aging population and in the progression of aging-related diseases, such as sarcopenia, osteopenia, and cognitive disorders, may reflect, in part, the natural polymorphisms of key catabolic and/or anabolic gene products. For example, molecular diversity in the glucocorticoid receptor may influence the relative effects of cortisol excess on tissue catabolism. Conversely, polymorphisms of the IGF-I receptor could be relevant in mediating interindividual differences in tissue atrophy in aging. A more systematic evaluation of this issue will require additional studies in various ethnic populations.[9]