Johannes D. Veldhuis, MD


March 15, 2000

In This Article

Biologic Origins of Aging

There is limited evidence that genetics plays a role in the aging process per se, although the genomic complement regulates longevity. Aging at the molecular level can be viewed as a stochastic process resulting from increased disorderliness of intra- and intercellular regulatory mechanisms. This results in reduced robustness of the organism to intercurrent stress and disease. The notion of greater disorderliness in aging is also evident at the whole organismic level, as illustrated by the erosion of the orderly neuroendocrine feedback regulation of the secretion of GH, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and adrenocorticotropin hormone (ACTH).[1]