Methods and Patients
The local ethics committee approved the study. All subjects received full information about the study before giving signed consent. Thirty-four subjects were studied: nine Europid non-diabetic controls, and 12 non-neuropathic and 13 neuropathic Europid diabetic patients. All subjects were free from any pathology that could affect their walking and peripheral vascular disease. All subjects underwent neuropathic evaluations. Dynamic foot pressures were measured and dynamic footprints were made for all subjects.
All subjects underwent quantitative sensory testing on their dominant lower limbs. Pressure perception threshold (PPT) was assessed using a set (1, 10, and 75 gram) of Semmes Weinstein monofilaments (Gillis W. Long Hansens's Disease Centre, Carville, LA, USA) at the dorsum of the foot and under the first MTH, fifth MTH, and the heel. Warm temperature perception threshold (TPT) was assessed on the dorsum of the foot using a thermoesthesiometer, comprising of two thermostimulators operating on the Peltier principle (VU, Amsterdam, The Netherlands). Vibration perception threshold (VPT) was measured using the Neurothesiometer (Horwell, Nottingham, UK) at the pulp of the hallux. Motor nerve conduction velocity (MNCV) of the Peroneal nerve was assessed using the MS92a EMG machine (Medelec limited, Old Woking, Surrey, UK).
Wounds. 2000;12(4) © 2000 Health Management Publications, Inc.
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