The Effects of TGF-b3 Modulation on Scar Tissue Formation in the Pig

Nathan D. Schwade, PhD, James J. Fowler, MD, Joseph Leach, MD, Department of Otolaryngology - Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas


Wounds. 2000;12(2) 

In This Article


Injected TGF-b3 and its antibody were shown to significantly alter breaking strength and fibroblast activity in porcine wounds within two weeks post injury. That manipulation of this growth factor modifies scar quality and wound strength is encouraging. Altering the level of specific growth factors within the wound milieu promises to give the clinician better control over problem wound situations in the future.


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