Lysine for Management of Herpes Labialis

Frankie A. Tomblin, Jr., Pharm.D. and Kristy H. Lucas, Pharm.D.


Am J Health Syst Pharm. 2001;58(4) 

In This Article

Adverse Effects

Six to 10 g of lysine is consumed daily in the average adult diet. Thus, it has been hypothesized that supplementation with 3000 mg/day will not cause serious adverse effects.[11] Information on lysine's safety is limited but serious adverse effects have been reported. In one case, a 44-year-old woman developed Fanconi's syndrome, manifested as tubulointerstitial nephritis, after taking 3000 mg of lysine daily for five years.[21] Abdominal pain and diarrhea occurred in patients who received 10 g/day for five days.[22] Other reports either do not provide safety information or state that no adverse effects were observed.


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