Lysine for Management of Herpes Labialis

Frankie A. Tomblin, Jr., Pharm.D. and Kristy H. Lucas, Pharm.D.

Disclosures

Am J Health Syst Pharm. 2001;58(4) 

In This Article

Pharmacokinetics

Extensive pharmacokinetic data for lysine are lacking. Lysine is transported across cellular membranes by two transport systems.[7] Studies suggest that lysine is rapidly transported into muscle tissue [8] and that lysine concentrations in muscle exceed those of other amino acids, especially at five to seven hours after ingestion. [9] Free lysine monohydrochloride is absorbed from dietary sources at the same rate as lysine, so supplementation would be likely to be effective in correcting lysine deficiency.[10] Lysine is the most highly conserved amino acid. This allows humans who consume a nitrogen-balanced diet (a diet consisting of 1 g of protein per pound of body weight daily) to have very low lysine requirements.[11] Catabolism occurs primarily in the liver.

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