Conclusion
Pharmacokinetic interactions between cyclosporine and sertraline, losartan, valsartan, quinine, atorvastatin, simvastatin, pravastatin, fluvastatin, alendronate, digoxin, acyclovir, and oxycodone were identified. Further studies of the interaction mechanisms are needed. Transplant patients 60-75 years of age had cyclosporine-drug interactions similar to those in younger patients, suggesting that aging in and of itself is not a risk factor for interactions involving cyclosporine.
Supported by the 1998 ASHP Research and Education Foundation/ Novartis Fellowship in Geriatric Pharmacotherapy.
Address reprint requests to Dr. Lill at the University of Washington Medical Center, 1959 N.E. Pacific Street, Box 356015, Seattle, WA 98195-6015.
Am J Health Syst Pharm. 2000;57(17) © 2000 American Society of Health-System Pharmacists
Presented in part at the ASHP Midyear Clinical Meeting, Las Vegas, NV, December 9, 1998.
Comments