Cyclosporine -- Drug Interactions and the Influence of Patient Age

Jennifer Lill, Larry A. Bauer, John R. Horn, and Philip D. Hansten


Am J Health Syst Pharm. 2000;57(17) 

In This Article


Pharmacokinetic interactions between cyclosporine and sertraline, losartan, valsartan, quinine, atorvastatin, simvastatin, pravastatin, fluvastatin, alendronate, digoxin, acyclovir, and oxycodone were identified. Further studies of the interaction mechanisms are needed. Transplant patients 60-75 years of age had cyclosporine-drug interactions similar to those in younger patients, suggesting that aging in and of itself is not a risk factor for interactions involving cyclosporine.


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