Angiotensin II-Receptor Antagonists: An Overview

Raquel Dina and Mahtab Jafari

Disclosures

Am J Health Syst Pharm. 2000;57(13) 

In This Article

Formulary Recommendations

Angiotensin-II-receptor antagonists seem to be as effective as ACE inhibitors for treating hypertension and can be initiated in patients who are unable to tolerate an ACE inhibitor. All available AT-II-receptor antagonists seem to be equally effective in reducing both systolic and diastolic blood pressure, and they are comparable in cost.

Losartan is unique among AT-II-receptor antagonists in that it has the ability to increase uric acid excretion, which in turn lowers plasma uric acid levels 22 ; however, the clinical importance of this characteristic has yet to be determined.

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