Angiotensin-II-receptor antagonists seem to be as effective as ACE inhibitors for treating hypertension and can be initiated in patients who are unable to tolerate an ACE inhibitor. All available AT-II-receptor antagonists seem to be equally effective in reducing both systolic and diastolic blood pressure, and they are comparable in cost.
Losartan is unique among AT-II-receptor antagonists in that it has the ability to increase uric acid excretion, which in turn lowers plasma uric acid levels 22 ; however, the clinical importance of this characteristic has yet to be determined.
Am J Health Syst Pharm. 2000;57(13) © 2000 American Society of Health-System Pharmacists
Cite this: Angiotensin II-Receptor Antagonists: An Overview - Medscape - Jul 01, 2000.