Angiotensin II-Receptor Antagonists: An Overview

Raquel Dina and Mahtab Jafari

Am J Health Syst Pharm. 2000;57(13)

Instructions for the Patient

Women of childbearing age should be advised of the consequences of second- and third-trimester fetal exposure to AT-II-receptor antagonists and should be instructed to report their pregnancy to their physician as soon as possible. Patients taking losartan should be advised not to use potassium supplements or salt substitutes containing potassium because of the potential for increased serum potassium levels.

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Abstract and Introduction
The Renin-Angiotensin Receptor System
Inhibitors of the Renin- Angiotensin System
Losartan Potassium
Valsartan
Irbesartan
Candesartan Cilexetil
Eprosartan Mesylate
Telmisartan
Tasosartan
Comparative Efficacy
Adverse Reactions
Drug Interactions
Cost
Instructions for the Patient
Indications
Formulary Recommendations
Conclusion
References

Table 1. Comparison of Angiotensin II-Receptor Antagonists
Drug	Active Metabolite	Bioavailability (%)	Daily Dose (mg)	Half-life (hr)	Cost ($)a
Losartan	Yes	33	25-100	2 (losartan) 6-9 (EXP-3174)	38
Valsartan	No	25	80-320	6	36
Irbesartan	No	60-80	150-300	11-15	36
Candesartan	No	42	8-32	3-4 3-11	36
Eprosartan	No	13	600-800	5-9	37
Telmisartan	No	42-58	20-80	24	39

a Estimated cost, based on average wholesale price (Drug Topics Red Book, 1999), to the pharmacist for a one-month supply at the usual starting dosage.

Table 2. Clinical Trials Comparing Angiotensin-II-Receptor Antagonists with Angiotensin-Converting-Enzyme Inhibitors a
a	Losartan dosages are expressed in terms of losartan potassium, and candesartan dosages are expressed in terms of candesartan cilexetil. BP = blood pressure, SBP = systolic blood pressure, DBP = diastolic blood pressure, NR = not reported, HCTZ = hydrochlorothiazide.
b	Primary efficacy variable was assessed after eight weeks of therapy.

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Angiotensin II-Receptor Antagonists: An Overview

Instructions for the Patient

Tables

Tables

References

Authors and Disclosures

Authors and Disclosures

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