First Reports of Adverse Drug Reactions (ADRs) In Recent Weeks


The following table contains an overview of first published case reports of adverse drug reactions identified in the international literature in recent weeks. Any claim to a 'first report' is verified by a database search of previous literature.

Drug and ADR Reference
Alosetron: ischaemic colitis Friedel D, Thomas R, Fisher RS. Ischaemic colitis during treatment with alosetron. Gastroenterol 2001 Feb; 120: 557-60
Bromazepam withdrawal: catatonia (serious) Deuschle M, Lederbogen F. Benzodiazepine withdrawal-induced catatonia. Pharmacopsychiatry 2001 Jan: 34: 41-2
Cefcapene pivoxil: skin eruption Kawada A, Aragane Y, Maeda A, et al. Drug eruption induced by cefcapene pivoxil hydrochloride. Contact Dermatitis 2001 Mar; 44: 197
Edodekin alfa: haemolytic anaemia and neutropenia with bone marrow agranulocytosis (serious) Gollob JA, Veenstra KG, Mier JW, et al. Agranulocytosis and hemolytic anemia in patients with renal cell cancer treated with interleukin-12. J Immunother 2001 Feb; 24: 91-8
Lithium: follicular mycosis fungoides Francis GJ, Silverman AR, Saleh O, et al. Follicular mycosis fungoides associated with lithium. J Am Acad Dermatol 2001 Feb; 44: 308-9
Meloxicam: ischaemic colitis (serious) Garcia B, Ramaholimihaso F, Diebold M-D, et al. Ischaemic colitis in a patient taking meloxicam. Lancet 2001 Mar 3; 357: 690
Mycophenolate mofetil: ischaemic colitis (serious) Kim HC, Park SB. Mycophenolate mofetil-induced ischaemic colitis. Transplantation Proceedings 2000 Nov; 32: 1896-7
Orlistat: liver failure (serious) Montero JL, Muntané J, Fraga E, et al. Orlistat associated subacute hepatic failure. J Hepatol 2001 Jan; 34: 173
Oxybuprocaine: allergic contact dermatitis following ophthalmic administration Blaschke V, Fuchs T. Periorbital allergic contact dermatitis from oxybuprocaine. Contact Dermatitis 2001 Mar; 44: 198
Tacrolimus: interaction with concomitant fluconazole leading to leucocyte disorders Gondo H, Okamura C, Osaki K, et al. Acquired Pelger-Huët anomaly in association with concomitant tacrolimus and fluconazole therapy following allogeneic bone marrow transplantation. Bone Marrow Transplantation 2000 Dec; 26 (11): 1255-7

Serious = an event is serious (FDA MedWatch definition) when the patient outcome is death, life-threatening, hospitalisation, disability, congenital anomaly, or requires intervention to prevent permanent impairment or damage.