First Reports of Adverse Drug Reactions (ADRs) In Recent Weeks

Drug Ther Perspect. 2001;17(7) 


The following table contains an overview of first published case reports of adverse drug reactions identified in the international literature in recent weeks. Any claim to a 'first report' is verified by a database search of previous literature.

Drug and ADR Reference
Alosetron: ischaemic colitis Friedel D, Thomas R, Fisher RS. Ischaemic colitis during treatment with alosetron. Gastroenterol 2001 Feb; 120: 557-60
Bromazepam withdrawal: catatonia (serious) Deuschle M, Lederbogen F. Benzodiazepine withdrawal-induced catatonia. Pharmacopsychiatry 2001 Jan: 34: 41-2
Cefcapene pivoxil: skin eruption Kawada A, Aragane Y, Maeda A, et al. Drug eruption induced by cefcapene pivoxil hydrochloride. Contact Dermatitis 2001 Mar; 44: 197
Edodekin alfa: haemolytic anaemia and neutropenia with bone marrow agranulocytosis (serious) Gollob JA, Veenstra KG, Mier JW, et al. Agranulocytosis and hemolytic anemia in patients with renal cell cancer treated with interleukin-12. J Immunother 2001 Feb; 24: 91-8
Lithium: follicular mycosis fungoides Francis GJ, Silverman AR, Saleh O, et al. Follicular mycosis fungoides associated with lithium. J Am Acad Dermatol 2001 Feb; 44: 308-9
Meloxicam: ischaemic colitis (serious) Garcia B, Ramaholimihaso F, Diebold M-D, et al. Ischaemic colitis in a patient taking meloxicam. Lancet 2001 Mar 3; 357: 690
Mycophenolate mofetil: ischaemic colitis (serious) Kim HC, Park SB. Mycophenolate mofetil-induced ischaemic colitis. Transplantation Proceedings 2000 Nov; 32: 1896-7
Orlistat: liver failure (serious) Montero JL, Muntané J, Fraga E, et al. Orlistat associated subacute hepatic failure. J Hepatol 2001 Jan; 34: 173
Oxybuprocaine: allergic contact dermatitis following ophthalmic administration Blaschke V, Fuchs T. Periorbital allergic contact dermatitis from oxybuprocaine. Contact Dermatitis 2001 Mar; 44: 198
Tacrolimus: interaction with concomitant fluconazole leading to leucocyte disorders Gondo H, Okamura C, Osaki K, et al. Acquired Pelger-Huët anomaly in association with concomitant tacrolimus and fluconazole therapy following allogeneic bone marrow transplantation. Bone Marrow Transplantation 2000 Dec; 26 (11): 1255-7

Serious = an event is serious (FDA MedWatch definition) when the patient outcome is death, life-threatening, hospitalisation, disability, congenital anomaly, or requires intervention to prevent permanent impairment or damage.