Improves Sexual Function
Hypogonadism contributes to the declining sexual function associated with aging. A plasma testosterone level below 2.0 to 4.5 µg/L is associated with impaired sexual behaviour in men. Whether administered intramuscularly, transdermally or orally, testosterone improved both sexual performance and attitude.[9,10]
When men were treated with intramuscular testosterone, then re-treated via the transdermal route (after a testosterone-free withdrawal period), the number of erectile events per day, mean duration of events, and mean penile rigidity increased significantly during the treatment periods compared with the withdrawal period. Libido, arousal, sexual desire, orgasm and satisfaction significantly decreased during the drug-free period, and returned during follow-up treatment.
Oral testosterone undecanoate also improved sexual attitudes and performance in 61% of hypogonadal men with impotence.
The anabolic effects of androgens are well known. Elderly hypogonadal men had increased lean body mass, leg muscle strength and upper body strength after oral or intramuscular testosterone treatment.
In tandem, fat mass was found to decrease after testosterone replacement. Visceral fat declined with testosterone therapy in both patients with acquired hypogonadism and those with abdominal obesity.
For the past 30 years evidence has accumulated demonstrating the benefit of androgens in the treatment of anaemias. For example, when testosterone was administered to older hypogonadal men over a 12-month period, a significant increase in haematocrit values was observed.
In older men, many studies have found that androgen replacement increased the sense of well being, enhanced spatial cognition and had an antidepressant effect.
In contrast, one study has found that in men with erectile dysfunction, biweekly testosterone enanthate had no effect on their affective state or psychological symptoms.
© 2000 Adis Data Information BV
Cite this: Testosterone: The Male HRT for Andropause - Medscape - Nov 01, 2000.