Drug-Induced Nail Disorders: Prevention Is Best

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Nail Fold Involvement is Painful

In acute drug-induced paronychia, the nail folds appear intensely red, erythematous and are extremely tender. One or several nails may be involved and the event usually develops soon after drug administration. Paronychia frequently develops during treatment with methotrexate,[4] retinoids,[5] and in HIV-infected patients receiving multiple-drug therapy including the nucleoside analogue lamivudine[6] and/or the protease inhibitor indinavir.[7,8]

Topical treatment with an antibiotic in the morning and a corticosteroid in the evening should be considered in patients with drug-induced paronychia and periungual inflammation.[1]


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