Place of Other Agents Less Clear
There is some evidence that clonidine, a centrally acting inhibitory presynaptic alpha2-adrenergic agent, has a favourable effect on uraemic and idiopathic RLS, although reports have been contradictory. The GABA-ergic agonist baclofen has also been reported to improved RLS symptoms and sleep quality, but not to reduce frequency of PLMS. Other agents that have been tried include propranolol, tricyclic antidepressants, and 5-hydroxytryptophan and L-tryptophan.[1,2] Anecdotal reports suggest benefit of tocopherol (vitamin E), ascorbic acid (vitamin C) and magnesium supplements.
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Cite this: Drug Treatment Available for Patients With Severe Restless Legs Syndrome - Medscape - Jun 19, 2000.