Drug Treatment Available for Patients With Severe Restless Legs Syndrome

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Anticonvulsants When Others Fail

Carbamazepine 200 to 400 mg/day reduces nocturnal symptoms in patients with RLS, but does not appear to reduce PLMS frequency. It is not as potent as dopaminergic or opioid drugs, and should be reserved for patients in whom other treatments have failed or are not suitable.[1] Gabapentin, a compound structurally related to gamma-aminobutyric acid (GABA), is under investigation as a well tolerated possible alternative treatment.


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