Drug Treatment Available for Patients With Severe Restless Legs Syndrome

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Benzodiazepines a Useful Alternative

The benzodiazepines were the first drugs to be investigated for use in RLS in the twentieth century. Clonazepam, which reduces PLMS and improves sleep, is currently the most favoured of this group;[1] treatment should be started at the low dosage of 0.5 mg/day and increased gradually as necessary. In some cases, dosages as high as 4 mg/day have been used.[1] Triazolam has been shown to improve sleep and to reduce PLMS-related arousal but not the number of PLMS episodes.[13] Diazepam does not appear to be of use in RLS.


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