Minimising Peripheral Neuropathy in Patients Treated With HAART

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Peripheral Neuropathy in Untreated HIV...

A predominantly sensory distal symmetrical polyneuropathy is the most common form of peripheral nervous system problem in HIV-infected individuals.[2] The incidence increases with falling CD4+ cell count. Prior to the availability of antiretroviral therapy, this peripheral neuropathy was reported in 30 to 35% of those with symptomatic HIV infection. For patients with a CD4+ cell count <100/µl the estimated annual incidence of neuropathy is 8%.[2] HIV-associated peripheral neuropathy commonly presents as distal paraesthesia, beginning with the toes and moving proximally, and is associated with pain in 10 to 60% of patients.[2]

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