Identification of Relevant Cancer Antigens for Vaccine Development

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Criteria for Cancer Vaccine Effectiveness

There are two key elements for consideration in the design of an effective vaccine for cancer: the selection of the tumor antigens used to construct the vaccine, and the procedure used to augment the ability of these antigens to stimulate anti-tumor immune responses. In addition, to be clinically useful, cancer vaccines should be safe, effective against a broad range of tumors of the same histologic type, potent enough to require only a few immunizations, stable in storage for prolonged periods, able to be manufactured reproducibly, and simple to use. Unfortunately, no such vaccine is currently available. The major barrier is that the identity of the tumor antigens that induce protective immunity -- and that should be used to construct the vaccine -- is unknown.

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