Identification of Relevant Cancer Antigens for Vaccine Development

Criteria for Cancer Vaccine Effectiveness

There are two key elements for consideration in the design of an effective vaccine for cancer: the selection of the tumor antigens used to construct the vaccine, and the procedure used to augment the ability of these antigens to stimulate anti-tumor immune responses. In addition, to be clinically useful, cancer vaccines should be safe, effective against a broad range of tumors of the same histologic type, potent enough to require only a few immunizations, stable in storage for prolonged periods, able to be manufactured reproducibly, and simple to use. Unfortunately, no such vaccine is currently available. The major barrier is that the identity of the tumor antigens that induce protective immunity -- and that should be used to construct the vaccine -- is unknown.

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Cite this: Identification of Relevant Cancer Antigens for Vaccine Development - Medscape - Jan 01, 2001.

Introduction
Criteria for Cancer Vaccine Effectiveness
Selection of Antigens to Be Used for Vaccine Construction
Implications for Cancer Vaccine Development
Rationale for Preparing Partially Purified Cancer Vaccines From Shed Antigens
Procedures to Augment the Immunogenicity of Antigens in Cancer Vaccines
Summary and Future Directions
References

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