Key Studies in Migraine From AAN 2022

Jessica Ailani, MD


May 03, 2022

Dr Jessica Ailani, from the MedStar Georgetown Headache Center in Washington, DC, reports on studies in migraine presented at the 2022 American Academy of Neurology (AAN) Annual Meeting.

She begins with a study investigating the potential use of functional MRI results of abnormal pons-to-hypothalamus connectivity in migraine patients as a biomarker for disease progression.

Next, Dr Ailani discusses two abstracts drawn from CaMEO, a web-based, longitudinal study of patients with migraine in the United States. The first presentation sought to link experience of common pre-migraine (prodrome) features to patient awareness of an impending migraine attack. The second study, using scores from the Migraine-Specific Quality-of-Life questionnaire, measured the impact of monthly migraine frequency on patients' allodynia, anxiety, and depression to show a direct effect of the number of headache days to quality-of-life scores.

Finally, Dr Ailani reports on two studies focusing on migraine and pregnancy outcomes. For the first, she reports findings showing that pregnant women with migraine history are at higher risk for preeclampsia, preterm delivery, and gestational hypertension. These adverse pregnancy outcomes, Dr Ailani explains, are further supported by data from the nuMoM2b study, which followed over 10,000 first-time mothers from early pregnancy through delivery.


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