CAR T-Cell Therapy Highlights From the 2019 ASH Annual Meeting

Michael R. Bishop, MD


January 02, 2020

At the 2019 American Society of Hematology annual meeting, a number of presentations covered chimeric antigen receptor (CAR) T cells. CAR T-cell therapies have demonstrated high response rates across hematologic cancers. Dr Michael Bishop highlights salient therapies that are likely to garner approvals in the near future.

In a study of KTE-X19 in patients with refractory/relapsed mantle cell lymphoma, updated results from ZUMA-2 showed that in 68 patients, the overall response rate (ORR) was 93%, and the complete response was 67%. With these impressive findings, Dr Bishop suggests that KTE-X19 is poised for FDA approval in mantle cell lymphoma.

Lisocabtagene maraleucel (liso-cel) targets CD19, but it is uniquely manufactured in a fixed ratio of CD4+ and CD8+ T cells. Liso-cel produced impressive responses in patients with large B-cell lymphomas, such as DLBCL (studied in TRANSCEND NHL00).

Finally, in CARTITUDE-1, JNJ-4528 was studied in patients with multiple myeloma. This study created a buzz because it showed 100% ORR, of which 69% were stringent complete responses.

The unique toxicities of CAR T-cell therapies, such as cytokine release syndrome, are being better managed with tocilizumab and corticosteroids.


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