Chronic Kidney Disease Expert Column

 
 
  • Niacin and Niacinamide for Hyperphosphatemia in the Dialysis Patient Drs. Steven Cheng and Daniel Coyne from Washington University School of Medicine summarize recent evidence on the effect of niacinamide and niacin on reducing serum phosphate in dialysis patients.
  • The Kidney-Bone-Vascular Axis in Chronic Kidney Disease Gerard M. London, MD, Chief of Nephrology at Manhes Hospital, discusses the bone-vascular axis and the consequences of deteriorating renal function including extraosseous and arterial calcifications.
  • Kidney Transplant Patients Should Be Managed Like Other Patients With CKD Bryan N. Becker, MD, from the University of Wisconsin School of Medicine and Public Health, analyzes the similarities in management between kidney transplant recipients and CKD patients.
  • Iron Therapy in CKD Patients -- Harm or Benefit? Rajiv Agarwal, MD, Professor of Medicine at Indiana University, discusses the risks and benefits of IV iron therapy, including how parenteral iron therapy may be used given this risk-benefit profile.
  • Survival Impact of Vitamin D Therapy in Hemodialysis Patients Lavinia Aura Negrea, MD, Assistant Professor of Medicine at Case Western University, reviews recent survival data and the role of vitamin D supplementation in patients with chronic kidney disease.
  • Vitamin D and the Diabetic Patient Daniel W. Coyne, MD, Professor of Medicine at Washington University, describes the consequences of low vitamin D and the potential to increase the risk for diabetes mellitus.
  • Reasons for the Decrease in Peritoneal Dialysis Utilization in the US Fredric O. Finkelstein, MD, Clinical Professor of Medicine at Yale University, discusses reasons for the decrease in peritoneal dialysis in the United States and ways to increase utilization of PD.
  • Serum Creatinine Increases and RAAS Blocker Therapy: An Update Madhav Rao, MD, and George Bakris, MD, from the University of Chicago review data demonstrating the benefits of ACEIs or ARBs in slowing CKD progression in those with advanced proteinuric nephropathy.
  • Management of Changes in Serum Creatinine and/or Potassium Concentration Biff F. Palmer, MD, discusses the optimal treatment of blood pressure in patients with CKD, particularly in those patients with increased serum creatinine and hyperkalemia.
  • Vitamin D Metabolism and Treatment in Chronic Kidney Disease Bryan R. Kestenbaum, MD, MS, from the University of Washington, reviews vitamin D metabolism in normal individuals and those with chronic kidney disease and vitamin D treatment options.
  • New Erythropoietins Ajay Singh, MB, MRCP, from Brigham and Women's Hospital in Boston, Massachusetts, provides a comprehensive review of new erythropoietins for the management of anemia of chronic kidney disease.
  • The Vagaries of the Parathyroid Hormone Assay Accurate measurement of PTH is essential in the diagnosis and management of mineral ion and skeletal disorders, and standardization of PTH assays is needed.
  • FDA Hearing on ESA Labeling Drs. Alan S. Kliger and Jonathan Himmelfarb highlight key points from the recent FDA hearing on use of ESAs in anemia. The FDA will soon make its decision regarding label indications for ESA use.
  • Exercise and Chronic Kidney Disease Matthew Beekley, PhD, Assistant Professor in the Department of Kinesiology at the University of Indianapolis, addresses the usefulness of both cardiovascular and resistance exercise for CKD.
  • Hemoglobin Targets, ESA Use, and FDA Upcoming Hearings Renowned nephrologists Adeera Levin, MD, and Allen Nissenson, MD, reflect on the controversy over hemoglobin targets, ESA use, the recent CHOIR and CREATE studies, and the upcoming FDA hearing.
  • Anemia and Erythropoietin: The FDA and CRAC Dr. Ajay Singh, from Harvard Medical School in Boston, comments on the upcoming Cardio-Renal Advisory Committee (CRAC) meeting where they will reconsider the epoetin and darbepoetin label for CKD.
  • Update on Nutrition and Chronic Kidney Disease Matthew Beekley, PhD, Assistant Professor in the Department of Kinesiology at the University of Indianapolis, answers common questions regarding the management of nutrition and chronic kidney disease.
  • Mineral-Bone Disorder of Chronic Kidney Disease Epidemiologic observational studies have shown that the currently used doses of different vitamin D metabolites and analogs have been associated with improvement in vascular function and survival.
  • Epoetin Therapy Risks and Benefits: Just the Facts Drs. Daniel W. Coyne and Ajay K. Singh answer questions surrounding the recent US Food and Drug Administration safety alert on use of ESAs, enabling clinicians to make informed management decisions.
  • Calcimimetic Therapy for Secondary Hyperparathyroidism Dr. Daniel Coyne examines the use and relative merits of cinacalcet in the treatment of secondary hyperparathyroidism.