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In Vitro Performance of Two Metered-Does Inhalers
The use of a valved holding chamber (VHC) with any metered-dose inhaler (MDI) promotes aerosol delivery in patients who lack essential coordination to effectively use the MDI alone.
Journal Article, December 01, 2003
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Comparative Pharmacokinetic Analysis
The standard two-stage method is a widely used analytic method in pharmacokinetic studies; it is relatively easy to perform and only requires software programs capable of handling single data sets.
Journal Article, December 01, 2003
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Correlation of Lamotrigine Concentrations
Until the past decade, when nine new antiepileptic drugs were approved by the United States Food and Drug Administration, the pharmacologic options for managing epilepsy were confined to a small number of drugs.
Journal Article, December 01, 2003
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Wood Creosote, the Principal Active Ingredient of Seirogan
Diarrhea is recognized as a major health problem and one of the leading causes of infant mortality in developing countries.
Journal Article, November 01, 2003
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Effects of the Angiotensin II Subtype 1 Receptor
In 2000, 519,000 coronary artery bypass graft (CABG) procedures were performed in the United States for treatment of coronary artery disease.
Journal Article, November 01, 2003
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Exploring the Association Between Atypical Neuroleptic Agents
Since their introduction in the late 1980s, the atypical neuroleptic agents-clozapine, olanzapine, quetiapine, and risperidone-have had a profound impact on the management of schizophrenia.
Journal Article, November 01, 2003
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Clinical and Microbiologic Analysis
Extended-spectrum ß-lactamase (ESBL)-producing organisms are an increasing problem for practitioners dealing with infectious diseases.
Journal Article, October 01, 2003
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Comparing the Bispectral Index and Suppression Ratio
Increases in intracranial pressure frequently complicate the care of patients with anoxic or traumatic brain injury, subarachnoid or intracerebral hemorrhage, ischemic stroke, and other toxic or metabolic events.
Journal Article, September 01, 2003
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Effects of Grapefruit Juice on Intestinal P-glycoprotein
P-glycoprotein (P-gp) is a membrane-bound protein encoded by the human multidrug-resistance-1 (MDR1) gene that acts as an efflux pump to transport a variety of compounds out of mammalian cells.
Journal Article, August 01, 2003
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Long-Term Spinal Cord Injury
Spinal cord injury (SCI) in humans leads to motor, sensory, and autonomic dysfunction.
Journal Article, July 01, 2003
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Effects of Didanosine Formulations on the PK of Amprenavir
Amprenavir is a human immunodeficiency virus (HIV) protease inhibitor that, in combination with nucleoside reverse transcriptase inhibitors, is effective in the treatment of HIV infection.
Journal Article, July 01, 2003
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Metabolism of Tenofovir and Didanosine
Tenofovir disoproxil fumarate is an acyclic phosphate analog of adenosine recently approved for treatment of HIV-1 infection.
Journal Article, June 01, 2003
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Fracture Risks for Women in Long-Term Care
What is the prevalence of vitamin D deficiency in osteoporosis as assessed by peripheral bone mineral density in women living in a nursing home?
Journal Article, June 01, 2003
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Pharmacokinetic Responses of Rabeprazole
A study determining the pharmacokinetic and pharmacodynamic rationale for the optimum regimen of rabeprazole in Helicobacter pylori infection.
Journal Article, June 01, 2003
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Losartan and E3174 Pharmacokinetics
Do the differences in the pharmacokinetics of losartan and its E3174 metabolite exist in individuals with the CYP2C9*1/*1, *1/*2, *1/*3 genotypes?
Journal Article, June 01, 2003
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High-Dose Hepatitis B Vaccine
The objective of the following study is to increase the response rate to the hepatitis B vaccine in patients awaiting lung transplantation.
Journal Article, May 01, 2003
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Estradiol in Premenstrual Asthma
Determining the effect of estradiol in women with documented premenstrual asthma.
Journal Article, May 01, 2003
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Variability in Polyene Content and Cellular Toxicity
An in vitro evaluation of the different amphotericin B products on the US market.
Journal Article, May 01, 2003
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Aspirin Dosage and Thromboxane Synthesis
Is urinary 11-dehydrothromboxane B a marker of aspirin resistance?
Journal Article, May 01, 2003
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Once-Daily Dosing Algorithm for Neonates
Gentamicin is one of the most commonly prescribed antibiotics in neonates for sepsis. This study is to develop a once-daily dosing algorithm for neonates younger than 10 days.
Journal Article, May 01, 2003
