Original Research Articles

 
 
  • In Vitro Performance of Two Metered-Does Inhalers The use of a valved holding chamber (VHC) with any metered-dose inhaler (MDI) promotes aerosol delivery in patients who lack essential coordination to effectively use the MDI alone.
  • Comparative Pharmacokinetic Analysis The standard two-stage method is a widely used analytic method in pharmacokinetic studies; it is relatively easy to perform and only requires software programs capable of handling single data sets.
  • Correlation of Lamotrigine Concentrations Until the past decade, when nine new antiepileptic drugs were approved by the United States Food and Drug Administration, the pharmacologic options for managing epilepsy were confined to a small number of drugs.
  • Wood Creosote, the Principal Active Ingredient of Seirogan Diarrhea is recognized as a major health problem and one of the leading causes of infant mortality in developing countries.
  • Effects of the Angiotensin II Subtype 1 Receptor In 2000, 519,000 coronary artery bypass graft (CABG) procedures were performed in the United States for treatment of coronary artery disease.
  • Exploring the Association Between Atypical Neuroleptic Agents Since their introduction in the late 1980s, the atypical neuroleptic agents-clozapine, olanzapine, quetiapine, and risperidone-have had a profound impact on the management of schizophrenia.
  • Clinical and Microbiologic Analysis Extended-spectrum ß-lactamase (ESBL)-producing organisms are an increasing problem for practitioners dealing with infectious diseases.
  • Comparing the Bispectral Index and Suppression Ratio Increases in intracranial pressure frequently complicate the care of patients with anoxic or traumatic brain injury, subarachnoid or intracerebral hemorrhage, ischemic stroke, and other toxic or metabolic events.
  • Effects of Grapefruit Juice on Intestinal P-glycoprotein P-glycoprotein (P-gp) is a membrane-bound protein encoded by the human multidrug-resistance-1 (MDR1) gene that acts as an efflux pump to transport a variety of compounds out of mammalian cells.
  • Long-Term Spinal Cord Injury Spinal cord injury (SCI) in humans leads to motor, sensory, and autonomic dysfunction.
  • Effects of Didanosine Formulations on the PK of Amprenavir Amprenavir is a human immunodeficiency virus (HIV) protease inhibitor that, in combination with nucleoside reverse transcriptase inhibitors, is effective in the treatment of HIV infection.
  • Metabolism of Tenofovir and Didanosine Tenofovir disoproxil fumarate is an acyclic phosphate analog of adenosine recently approved for treatment of HIV-1 infection.
  • Fracture Risks for Women in Long-Term Care What is the prevalence of vitamin D deficiency in osteoporosis as assessed by peripheral bone mineral density in women living in a nursing home?
  • Pharmacokinetic Responses of Rabeprazole A study determining the pharmacokinetic and pharmacodynamic rationale for the optimum regimen of rabeprazole in Helicobacter pylori infection.
  • Losartan and E3174 Pharmacokinetics Do the differences in the pharmacokinetics of losartan and its E3174 metabolite exist in individuals with the CYP2C9*1/*1, *1/*2, *1/*3 genotypes?
  • High-Dose Hepatitis B Vaccine The objective of the following study is to increase the response rate to the hepatitis B vaccine in patients awaiting lung transplantation.
  • Estradiol in Premenstrual Asthma Determining the effect of estradiol in women with documented premenstrual asthma.
  • Variability in Polyene Content and Cellular Toxicity An in vitro evaluation of the different amphotericin B products on the US market.
  • Aspirin Dosage and Thromboxane Synthesis Is urinary 11-dehydrothromboxane B a marker of aspirin resistance?
  • Once-Daily Dosing Algorithm for Neonates Gentamicin is one of the most commonly prescribed antibiotics in neonates for sepsis. This study is to develop a once-daily dosing algorithm for neonates younger than 10 days.