Developments to Watch

 
 
  • Sorting Out Cognitive Deficits in Down Syndrome Dr. Huaxi Xu from Sanford-Burnham and Dr. William Mobley from UC San Diego discuss their collaborative efforts in exploring the molecular roots of impaired memory in Down syndrome.
  • The Microbiome: Linking Bacteria, Health, and Disease   Researchers are beginning to understand the effects that the trillions of bacteria that live in humans have on health and disease. How might this affect the future of clinical practice?
  • Treating Heart Failure Through Cardiac Regeneration   Advances in technology have allowed researchers to stimulate damaged cardiac muscle cells to regenerate in patients with heart failure. How might this affect the future of clinical practice?
  • Cardiomyopathy at the Intersection of Bench and Bedside Dr. Chen from Sanford-Burnham and Dr. Judge from Johns Hopkins discuss their collaborative efforts in developing a human stem cell-based model for an inherited cardiomyopathy.
  • Treating Type 1 Diabetes With Stem Cells: A New Way Forward   Advances in technology have allowed for a new way to transplant stem cell-derived beta cells for the treatment of type 1 diabetes. How might this affect the future of clinical practice?
  • Disease in a Dish: The Ultimate Personalized Medicine   Advances in stem cell technology have opened new avenues of research for identifying and personalizing treatments. How might this affect the future of clinical practice?
  • Keeping Hijackers at Bay: Novel Targets for Antivirals   Advances in our understanding of how viruses hijack host cell machinery has opened new avenues of research in antiviral therapy development. How might this affect patients with infectious diseases?
  • Beating Pathogenic Viruses and Bacteria at Their Own Game   Researchers are developing new tools to disrupt the mechanisms that bacteria and viruses use when inducing an infection. What might this mean for anti-infective approaches in the coming years?
  • Toward New Therapeutic Approaches for Autoimmune Diseases   A better understanding of the immune system is leading to the development of more targeted approaches to treating autoimmune diseases. How will this affect clinical practice in the coming years?
  • Overcoming Antibiotic Resistance   Advances in our understanding of how pathogens infect cells have opened new avenues of research in antibiotic resistance. How might this affect management of patients with infectious diseases?
  • Regulating Metabolism: From Obesity to Cancer   A better understanding of metabolism has led researchers to explore its role in diabetes, obesity, and cancer. What are the implications for clinical practice?
  • Understanding the Diabetic Heart   Molecular studies of cardiac dysfunction in patients with diabetes have opened new avenues of research on the intersection of these diseases. How might this affect management of the diabetic heart?
  • The Mosaic of Diabetes   Many organs beyond the pancreas are involved in the pathophysiology of diabetes. How does this view of the "mosaic" of diabetes change the way we look at the disease?
  • Exercise in a Pill?   New ways of looking at fat metabolism and muscle action in obesity have improved our understanding of the mechanisms behind the benefits of exercise. Is exercise in a pill the next step?
  • Finding the Right Drug for the Right Disease   Advances in drug screening and drug discovery are changing the way we move new agents from bench to bedside.
  • Tackling Diabetes and Obesity From a Different Angle   Metabolism regulation is key in heading off the development of obesity and type 2 diabetes and may prove to be a new avenue for therapeutic intervention in both of these disorders.
  • Harnessing the Power of Stem Cells in the Clinic   A greater understanding of stem cells is opening new insight into cancer growth and development. The next step is using this knowledge for new therapeutic approaches.
  • A New Frontier in Alzheimer Disease   The development of memantine opened a new avenue of research in Alzheimer disease and prompted new views on the importance of neuroprotection in treating this disease. Where do we go from here?
  • Welcome to Developments to Watch   This series of video programs highlights research at Sanford-Burnham Medical Research Institute and how it will affect clinical practice in the coming years.