Pulmonary Arterial Hypertension News

• ATS 2020 Treprostinil Improves Walk Distance in Pulmonary Hypertension Exercise capacity increased after patients with pulmonary hypertension associated with interstitial lung disease were treated with the vasodilator for 16 weeks, new research shows.
  Medscape Medical News, July 09, 2020
• ESC-HF 2020 Mortality Differs by LVEF Between Women and Men Clinically significant sex-based differences in left ventricular ejection fraction related to mortality emerged in a real-world, observational, big data study from Australia.
  Medscape Medical News, June 12, 2020
• Can Nitric Oxide Prevent COVID-19 Infection or Progression? Dr Lorenzo Berra, a Boston anesthesiologist and intensivist, discusses nitric oxide and its use in treating patients who are infected with COVID-19.
  Medscape Medical News, May 26, 2020
• Inhaled Nitric Oxide Eases COVID-19-Related Exacerbation of Pulmonary Arterial Hypertension Outpatient inhaled nitric oxide relieved dyspnea in a patient with vasoreactive idiopathic pulmonary arterial hypertension (PAH) who developed COVID-19, researchers report.
  Reuters Health Information, May 15, 2020
• Ultrasound Pulmonary Artery Denervation Promising in PAH Therapeutic intravascular ultrasound pulmonary-artery denervation is safe and reduces pulmonary vascular resistance in certain patients with pulmonary arterial hypertension, a new trial suggests.
  Reuters Health Information, May 13, 2020
• ATS 2020 Inhaled Nitric Oxide Explored for COVID-19 Oxygenation Clinicians filed an emergency application to treat a COVID-19 patient with pulmonary hypertension with nitric oxide from a tankless device at home, and their findings have spurred clinical trials.
  Medscape Medical News, May 13, 2020
• Mallinckrodt to Fund Trial to Test Nitric Oxide Therapy in COVID-19 Patients Mallinckrodt said on Thursday it would fund a trial conducted by medical experts, evaluating the potential benefits of its respiratory therapy, INOmax, as a treatment for lung complications in patients infected with the new coronavirus.
  Reuters Health Information, April 30, 2020
• Obesity Drug a New Treatment Option for Dravet Syndrome? Adding the obesity drug fenfluramine to an antiseizure medication regimen significantly reduces seizures in a rare, but severe, type of pediatric epilepsy, new research suggests.
  Medscape Medical News, December 02, 2019
• CHEST 2019 Combo Improves Blood Flow in Pulmonary Arterial Hypertension Results from the OPTIMA study suggest the combination of macitentan plus tadalafil is safe and effective and improves hemodynamics for patients with pulmonary arterial hypertension.
  Medscape Medical News, October 28, 2019
• Gadolinium Exposure Risk Highest in Early Pregnancy Pregnancy screening is key in preventing inadvertent exposure to gadolinium among women who undergo contrast-enhanced imaging procedures, a study found.
  Medscape Medical News, August 20, 2019
• Alert EU Panel Backs Closer Sartan Monitoring, Generic PAH Drug The European Medicines Agency is taking further steps to prevent future nitrosamine impurities in blood pressure and diabetes meds, and recommended approval for another generic for PAH.
  International Approvals, April 26, 2019
• Alert FDA Approves Letairis (Ambrisentan) Generics for PAH The agency also approved two shared system risk evaluation and mitigation strategy programs for ambrisentan ? Ambrisentan REMS (formerly Letairis REMS) and PS-Ambrisentan REMS.
  FDA Approvals, April 01, 2019
• High Dose of Sildenafil Tied to Long-term Retinal Damage Persistent red-tinted vision and cone photoreceptor damage were reported in a patient who had taken a large dose of the erectile dysfunction drug sildenafil.
  Medscape Medical News, October 02, 2018
• TCT 2018 PADN-5: Ablation Reduces Pulmonary Hypertension in HF Pulmonary artery denervation improved hemodynamic and clinical outcomes at 6 months, but design flaws in the sham-controlled study may muddy the results, a clinical trials expert cautions.
  Medscape Medical News, September 24, 2018
• ESC 2018 New ESC Guideline on Cardiovascular Disease in Pregnancy The document endorses a pregnancy heart team for care, advises inducing labor at 40 weeks, and provides a table on safety of cardiovascular drugs during pregnancy and breastfeeding.
  Medscape Medical News, September 05, 2018
• Adult Congenital Heart Disease Guidelines Get Major Overhaul A new classification system from ACC/AHA incorporates physiologic factors, not just anatomy alone, which experts say will allow more personalized care of this growing patient population.
  Medscape Medical News, August 20, 2018
• Trial Halted After 11 Infants Die in the Netherlands Researchers were testing whether sildenafil could improve growth among fetuses with fetal growth restriction by increasing blood flow to the placenta; all related trials have been halted.
  Medscape Medical News, July 25, 2018
• SCAI 2018 FLARE: Mechanical Thrombectomy Effective in Intermediate-Risk PE The ability to perform catheter-directed mechanical thrombectomy sans thrombolytics could be a game-changer in the treatment of acute pulmonary embolism, but experts caution it's early days.
  Medscape Medical News, May 01, 2018
• Methamphetamine Abuse Exacts Heavy Toll on the Heart A large case series sheds light on pulmonary arterial hypertension and dilated cardiomyopathy associated with methamphetamine abuse.
  Medscape Medical News, March 27, 2018
• AHA Device Therapy for Preserved-EF HF? Shunt Safely Eases LA Pressures The implant creates an 8-mm diameter shunt that unloads the left atrium, especially at exertion; sham-controlled REDUCE LAP-HF I suggests it could make select HFpEF patients more amenable to diuretics.
  Medscape Medical News, November 24, 2017