Genomics Perspective

• 25 Years of Brugada Syndrome, With Dr Josep Brugada The electrophysiologist of the eponymous channelopathy is interviewed about his discovery and where he sees the field going.
  theheart.org on Medscape, April 2018
• Was It Wrong for a Fertility Doc to Secretly Donate Sperm?   A woman who sent a DNA sample to a genetic testing company learned that a fertility doctor was her father. What should you say to patients about genetic tests?
  Medscape Business of Medicine, April 2018
• A Boy With Suddenly Failing Vision An otherwise healthy 5-year-old boy presents after a failed vision exam. What's causing the decline in his eyesight?
  Medscape Ophthalmology, April 2018
• Mosaicism and IVF Success Can mosaic embryos produce healthy euploid newborns?
  Medscape Ob/Gyn, April 2018
• ctDNA Shows Wide-Ranging Promise in Breast Cancer From breast cancer screening to detecting minimal residual disease after treatment, circulating tumor DNA testing has many promising applications in breast cancer management.
  Medscape Oncology, April 2018
• '100,000 Genomes' Project: Linking Genome Sequencing to Outcomes   Dr David Kerr shares thoughts on the 100,000 Genomes project linking whole genome sequencing to outcomes and the skepticism among some colleagues about the benefits of so-called actionable mutations.
  Medscape Oncology, April 2018
• APOE4 Gene Carriers Benefit From Lifestyle Improvements   Dr Isaacson reviews the findings from Karolinska Institutet's FINGER report that shows how lifestyle changes prevent cognitive decline even in genetically susceptible people who have the APOE4 gene.
  Medscape Neurology, March 2018
• From ALK to T790M: The Role of Liquid Biopsy in Lung Cancer While tissue biopsy is still the standard in lung cancer, there are a growing number of scenarios in which liquid biopsy may provide valuable information.
  Medscape Oncology, March 2018
• Why Donald Trump Is Better Off Knowing His Calcium Score A trio of preventive cardiologists take issue with a commentary questioning the utility of coronary calcium scores.
  Letters to the Editor, March 2018
• 'You Don't Always Need to Do More': De-escalating Breast Cancer Therapy Patients diagnosed with breast cancer could soon be benefiting from what could be described as the next step in personalized therapy: de-escalation of treatment to minimize adverse effects.
  Medscape Oncology, March 2018
• Psychotherapy Is 'The' Biological Treatment Dr Robert Berezin on the biology behind psychotherapy's effectiveness.
  Medscape Psychiatry, March 2018
• Is Genotype Screening Needed Before Fluoropyrimidines?   Dr David Kerr on how the recent case for DPYD screening may be on (and off) mark in addressing chemotherapy toxicity.
  Medscape Oncology, March 2018
• The Future of Medicine From a Leader in Biosensors   Dr Eric Topol talks with pioneering researcher John Rogers about how his flexible electronic devices are being used in medicine and what further developments lie ahead.
  Medscape, March 2018
• Genetic Mutations and Prostate Cancer: Screening Recommendations In light of recently published data, Dr David Graham suggests potential approaches to prostate cancer screening that incorporate genetic test results.
  Medscape Oncology, March 2018
• The Facts, Figures, and Faces of Migraine   Headache specialist Dr Lawrence C. Newman discusses how his patients experience migraine and what promising therapies are on the horizon.
  American Headache Society and Medscape, March 2018
• Why Is Obesity so Challenging? Is it genetic? Is it a simple matter of too much food and not enough exercise? Get to the bottom of this common condition that so many clinicians find extremely vexing.
  Endocrine Society, March 2018
• What Does Pfizer Backing Out of Alzheimer Research Mean to the Field?   Despite the abandonment of research by some pharmaceutical companies, Dr Isaacson is very hopeful about the future of Alzheimer disease treatment and prevention.
  Medscape Neurology, February 2018
• Digitizing the Mind to Understand Mental Health   New tools may make the diagnostic process less subjective in mental illness, paving the way for better therapeutics.
  Medscape, February 2018
• When Missing a 'Zebra' Can Land You in Court Physicians are generally unlikely to face a malpractice suit for misdiagnosing a rare disease, which affects about 1 in 10 people. But the results of a delayed or wrong diagnosis can be devastating or lethal.
  Medscape Business of Medicine, February 2018
• Overlooked Biomarker May Predict Cancer Immunotherapy Response   Dr David Kerr on data showing that tumors with extensive aneuploidy may not benefit as much from immune checkpoint blockade.
  Medscape Oncology, February 2018