Clinical Trials News

 
 
  • PrEP Dramatically Cuts New HIV Infections in Australia Pre-exposure prophylaxis (PrEP)dramatically reduced new infections in a large group of high risk gay men, Australian researchers report.
  • Thrill Seekers May Be More Pain Tolerant People who seek out thrilling experiences appear to be less sensitive to pain, according to a study by researchers at the University of Tulsa, Oklahoma.
  • A Novel Treatment Approach for PML Progressive multifocal leukoencephalopathy, caused by the JC virus, has no known treatment. A new study offers a novel approach using T-cell infusions from the more treatable BK virus.
  • AAO 2018Drug Pipeline for Macular Degeneration in Focus at AAO Updates from phase 3 trials of VEGF inhibitors for neovascular age-related macular degeneration, and a novel genetic treatment, will be highlighted at the American Academy of Ophthalmology meeting.
  • ESMO 2018Gender Differences in Chemo Side Effects Although outcomes and rates overall toxicity of esophagogastric cancer chemotherapy are similar for men and women, rates of nausea, diarrhea, and hair loss are higher in women, warn UK scientists.
  • ECTRIMS 2018Safe to Stop MS Disease-Modifying Therapy After Age 60? To add more evidence to the controversial debate over stopping immunomodulatory therapy for multiple sclerosis after age 60, researchers focus on quality of life, walking performance, and relapse rates.
  • Prenatal Fluoride Exposure Linked to ADHD in Kids To think that water fluoridation is unsafe has long been considered a fringe belief, but recent research suggests cause for concern.
  • Journal to Withdraw Chronic Fatigue Review Amid Patient Activist Complaints The decision, described by the scientists involved as 'disproportionate and poorly justified,' is being seen as a victory for activists in a research field plagued by uncertainty and dispute over whether CFS has physical and psychological elements.
  • Breast Tomosynthesis Better Than Mammography? A simplified, single-view version of digital breast tomosynthesis may increase the detection of breast cancer over standard digital mammography, with lower radiation exposure, say Swedish scientists.
  • Immunotherapy Combos: Will Cost Put Them out of Reach? Immunotherapy has already revolutionized cancer care. Combining various immunotherapies promises even greater success, but will the already high cost of these therapies put combos out of reach?
  • Amgen, Novartis Kick Off Fight for AbbVie Blockbuster Drug in EU Rival versions of the world's top-selling drug, AbbVie's Humira (adalimumab), went on sale in Europe on Tuesday, years ahead of similar cut-price copies being available in the United States.
  • Ketamine Dosing for Depression May Not Be 'One-Size-Fits-All' A study confirms the antidepressant effects of intravenous ketamine at the standard 0.5 mg/kg dose and hints that a lower dose might also have some benefit with fewer side effects.
  • HPV Vaccination Not Linked With Rise in Teen Risky Sex
  • Less Violent Behavior Seen in Teens Where Spanking Is Illegal Teens may be less likely to get in fist fights when they live in countries where it's illegal for parents to spank or slap children as punishment for bad behavior, an international study suggests.
  • Bayer May Outsource Some Drug Research - Works Council Bayer's chief executive is considering farming out certain drug research activities to cut costs amid slower growth at its pharmaceuticals division, the German company's works council said on Monday.
  • Children With CP May Have Worse Pain, Be Less Active When Parents Catastrophize If their parents catastrophize pain, children with cerebral palsy (CP) have worse pain and more impaired activities of daily living after intrathecal baclofen (ITB) surgery to control spasticity, according to results of a study presented last month at the International Association for the Study of Pain (IASP) World Congress on Pain in Boston.
  • Liquid Biopsy May Reveal Treatment Response in Pediatric Brain Tumors In children with diffuse midline glioma (DMG), liquid biopsy based on analyses of circulating tumor DNA (ctDNA) in cerebral spinal fluid (CSF) or plasma shows promise for detecting mutational load and may serve as tool for assessing tumor response to treatment, researchers say.
  • Urine Exosome Assay Could Curb Unnecessary Prostate Biopsies Exosome Diagnostics' ExoDx Prostate (IntelliScore) (EPI) urine exosome gene expression assay may help avoid unnecessary prostate biopsies, according to a large prospective study.
  • High Suicide Risk in Elderly Who Self-Harm Older adults who intentionally harm themselves are more likely to die by suicide, yet are often not referred for mental health services.
  • Two Drugs for Uterine Leiomyomas Show Promise Ulipristal acetate, a selective progesterone receptor modulator, and elagolix, an oral gonadotropin-releasing hormone receptor antagonist, are effective for the treatment of uterine leiomyomas, according to two industry-sponsored randomized controlled trials.