Nature Clinical Practice Rheumatology

 
 

  • Anti-neurotrophic Factor, a Possible Alternative for Treating Skeletal Pain Can nerve growth factor inhibitors be an effective alternative treatment for post-traumatic and post-operative skeletal pain, without impairing bone healing?
  • NICE Guidelines on Anti-tumor Necrosis Factor Therapy for RA This viewpoint explains the rationale and debate surrounding the NICE guidelines recommendation that patients in whom initial anti-TNF therapy is ineffective shouldn't switch to another TNF inhibitor.
  • Is Long-term Etanercept Therapy Safe and Effective in Patients With JRA? Juvenile rheumatoid arthritis can be difficult to treat, as not all traditional treatments are effective in patients. Can long-term etanercept therapy provide a safe and effective treatment option?
  • Relevance of Osteoproliferation as an Outcome Parameter in AS This viewpoint explores the relevance of osteoproliferation amongst other outcome parameters in akylosing spondylitis for monitoring the structural damage of the disease.
  • Vitamin D and Musculoskeletal Health Hypovitaminosis D, encompassing both vitamin D insufficiency and deficiency, is highly prevalent in the general population and has potentially deleterious musculoskeletal effects.
  • MicroRNAs, The Immune System and Rheumatic Disease MicroRNAs (miRNAs) have been implicated in the pathogenesis of rheumatic disease and are, therefore, a potential target for drug development. This review describes the well-established roles of miRNAs in hematopoiesis and the immune response.
  • Maintaining Remission in a Patient With Vasculitis In this Case Study, Drs Flossmann and Jayne describe the treatment of a patient with refractory Wegener's granulomatosis, and discuss the challenges associated with managing this disorder.
  • Therapy Insight: Rheumatic Disease in HIV Infection The impact of the global HIV pandemic continues to grow and rheumatologists need to be aware of the spectrum of rheumatic diseases that occur in HIV-positive individuals, as outlined in this review.
  • Adult Mesenchymal Stem Cells for Osteoarthritis Therapy In this review, the authors outline the potential use of strategies based on mesenchymal stem cells, which can differentiate into cells of the chondrogenic lineage, in the regeneration and maintenance of damaged articular cartilage.
  • TNF Converting Enzyme as a Pharmaceutical Target for RA Drugs that inhibit tumor necrosis factor provide considerable benefit in treatment of rheumatoid arthritis; however, there is an unmet medical need for alternative therapies.
  • A Paraneoplastic Case of Palmar Fasciitis and Polyarthritis Syndrome Rapidly progressive joint flexures are presented in a 58-year-old woman diagnosed with palmar fasciitis and polyarthritis syndrome associated with pancreatic carcinoma. Test your diagnostic acumen.
  • Safe Adalimumab Tx for Rheumatoid Arthritis in Multiple Myeloma Patient Rheumatoid arthritis is treated effectively with anti-tumor necrosis factor but with a possible risk of malignancy. How might treatment be safe and effective in patients with preexisting malignancies?
  • Diagnosing Pulmonary Artery Hypertension in a Woman With Systemic Sclerosis Rapid-onset dyspnea on exertion is presented in a 42-year-old woman with limited cutaneous systemic sclerosis. What are the challenges of diagnosing pulmonary arterial hypertension in this patient?
  • Conversion of Discoid Lupus to Antiphospholipid Syndrome and SLE A rare conversion of discoid lupus to antiphospholipid syndrome and systemic lupus erythematosus is presented in a 64-year-old man. What are the related diagnostic and management challenges?
  • Emerging Viral Infections and Arthritis The rheumatologist of this millennium will likely be called on increasingly to participate in the health care of afflicted travelers with new and emerging viral infections.
  • Nonpharmacologic Management of Osteoporosis to Minimize Fracture Risk Osteoporosis management has largely been through pharmacotherapy, but the inclusion of nonpharmacologic strategies is gaining support. Their mechanisms of action and potential effects are reviewed.
  • Adipokines As Emerging Mediators of Immune Response and Inflammation Adipokines derived from white adipose tissue play a role in inflammatory, autoimmune, and rheumatic diseases. The types and functions of identified adipokines in relation to inflammation are explored.
  • Behavioral Changes in Systemic Lupus Erythematosus are of Autoimmune Nature Neuropsychiatric signs in systemic lupus erythematosus are of an unknown nature. Do autoimmune factors affect neuropsychiatric expressions via direct and indirect autoantibody-induced neuronal damage?
  • Chronic Recurrent Multifocal Osteomyelitis: What is it, how Should it be tx Clinical diagnosis of chronic recurrent multifocal osteomyelitis is often difficult because symptoms and disease course vary a lot. A multi-disciplinary approach for diagnosis and therapy is featured.
  • Pain Measurement in Patients With Low Back Pain Accurate pain assessment is required for effective pain management but its systematic quantification is rare. Pain intensity scales and clinical presentations and characteristics of pain are reviewed.