Modern Pathology

 
 
  • Distinguishing Nodal Melanocytic Nevi From Metastatic Melanomas A well-known diagnostic pitfall in melanoma sentinel lymph node evaluation is the presence of nodal melanocytic nevi. This study tests the utility of two biomarkers for differentiating between the two.
  • Reproducibility of Subtypes in Pulmonary Adenocarcinoma This study assesses reproducibility in subtyping pulmonary adenocarcinomas and distinguishing between invasive and non-invasive patterns of adenocarcinoma.
  • ALK Alterations in Adult Renal Cell Carcinoma How prevalent are ALK alterations in renal cell carcinoma? This study looked at the frequency of these rearrangements in adult RCC as well as clinical and pathological features associated with them.
  • Concordance Between HercepTest and ERBB2 FISH In 2007, the ASCO/CAP proposed recommendations for HER2 immunohistochemistry and ERBB2 FISH scoring in an effort to improve diagnostic accuracy. Have these guidelines improved concordance rates?
  • Consensus Statement on the Pathology of IgG4-Related Disease This consensus statement, developed by a multi-specialty international symposium, provides practicing pathologists with a set of guidelines for the diagnosis of IgG4-related disease.
  • Immune Response in Melanoma This study assessed the utility of local immune profiles in both the primary tumor and the sentinel lymph node as prognostic markers in melanoma.
  • The Elucidation of Familial Colorectal Cancer Type X The genetic etiology of familial colorectal cancer type X remains largely unknown. Is exome sequencing the key to unlocking its genetic roots?
  • Comparing Assays for Estrogen and Progesterone Receptors Most labs use immunohistochemistry to determine ER and PR status in breast cancer specimens. This study evaluates a new assay that utilizes quantitative reverse transcription-PCR. Is it as sensitive?
  • Accuracy of HER2 Determination on Breast Core-needle Biopsies Which methodology provides the most accuracy in determining HER2 status in breast cancer core biopsy specimens? This study compares the most commonly used assays.
  • EGFR and KRAS Mutation Analysis in Lung Adenocarcinoma Mutation analysis is problematic in lung cancer cytology because of scant material. In this study, laser capture microdissection was used to assess for EGFR and KRAS mutations in lung adenocarcinoma.
  • p40 for the Diagnosis of Pulmonary Squamous Cell Carcinoma p40, a little known antibody that is highly specific for squamous and basal cells, could prove to be an important tool for accurate classification of non-small cell lung carcinoma.
  • Postradiation Cutaneous Angiosarcoma After Breast Cancer What is the role of MYC amplification in cases of cutaneous angiosarcoma resulting from radiation therapy for breast cancer? This study compared MYC expression in these patients with control cases.
  • Stem Cell Pathologies and Neurological Disease The authors address the potential role of stem cell pathology in a variety of neurological diseases. Does the presence of stem and progenitor cells in the adult human brain suggest a reparative role?
  • Quantitative Image Analysis of Diffuse Large B-Cell Lymphoma Is there any added clinical benefit over traditional immunohistochemistry in utilizing computer-driven quantitative image analysis to determine proliferation rates in diffuse large B-cell lymphoma?
  • Tubal Origin of 'Ovarian' Low-Grade Serous Carcinoma Do ovarian serous carcinomas originate in the ovary, or the fallopian tube? This study examines the morphologic and immunophenotypic evidence.
  • p53 as Surrogate Marker for TP53 Mutations in Ovarian Cancer This study seeks to clarify the relationship of the immunohistochemical expression of p53 with the mutational status of the TP53 gene in ovarian cancer.
  • Pioneering Pathologists of the Massachusetts General Hospital This fascinating article recounts the stories and contributions of some of the earliest trailblazers in pathology who practiced at the Massachusetts General Hospital during the late 19th to early 20th century.
  • Telomere Length in Histologic Types of Ovarian Carcinoma Longer telomeres in ovarian clear cell carcinoma are associated with increased mortality. Do aberrations in telomere length play an important role in the development and progression of this neoplasm?
  • Atypical Ductal Hyperplasia: Observer Variability Atypical ductal hyperplasia remains a diagnostic challenge with wide variation in interpretation among pathologists. Can an immunohistochemical stain lead to improved diagnosis?
  • Lymphatic and Blood Vessels in Triple-Negative Breast Cancer This study examines the vascular characteristics of lymphatic and blood vessels in breast cancers of basal and triple-negative phenotypes. How are these features associated with patient prognosis?