Clinical Drug Investigation

• Perindopril vs ARB in Hypertension and Coronary Artery Disease Initial assumptions were that these 2 drug types might be interchangeable, but ongoing research has revealed important differences.
  Clinical Drug Investigation™, March 01, 2007
• Treatment of Parkinson’s Disease The choice between available treatment options depends on clinical characteristics, but also on the education of the treating physician.
  Clinical Drug Investigation™, March 01, 2007
• Voriconazole vs Caspofungin for Invasive Aspergillosis One agent is more cost-effective than the other, especially in patients above a certain body weight.
  Clinical Drug Investigation™, March 01, 2007
• Cost Effectiveness of Imatinib Mesylate for Gastrointestinal Stromal Tumors This expensive treatment increases life expectancy to 5.8 years in these patients.
  Clinical Drug Investigation™, February 01, 2007
• Monophasic Estrogen-Progestogen Therapy in Postmenopausal Women Beneficial effects on sexuality and on hot flashes make this a promising option.
  Clinical Drug Investigation™, January 01, 2007
• Determining Factors in the Prescription of Moxifloxacin in ECB Antibacterial choice depended on factors related to both the prescribing physician and the patient.
  Clinical Drug Investigation™, February 01, 2007
• Clinical Effectiveness of Quetiapine in Children with Tourette's Syndrome This new atypical antipsychotic was associated with only one mild side-effect.
  Clinical Drug Investigation™, February 01, 2007
• Oral Antiviral Therapies for Chronic Hepatitis B Infection In this patient population, there were clear differences in the efficacies of entecavir, lamivudine, and adefovir.
  Clinical Drug Investigation™, January 01, 2007
• Zolmitriptan 5mg Nasal Spray for Treatment of Migraine Are your patients looking for something better to treat migraine? Most patients in this study wanted to keep using the test spray.
  Clinical Drug Investigation™, February 07, 2007
• Aripiprazole in the Treatment of Schizophrenia These dosing and administration recommendations represent best-practice guidelines for using aripiprazole in the acute and long-term treatment of schizophrenia.
  Clinical Drug Investigation™, January 01, 2007
• Tramadol in the Treatment of Neuropathic Cancer Pain Tramadol offers the benefits of both opioids and tricyclic antidepressants, making it a reasonable therapeutic option.
  Clinical Drug Investigation™, January 01, 2007
• Functional Half-Life is Meaningful in Steady-State Pharmacokinetics A new method is described to compute a practical and clinically relevant functional half-life for drugs with extended or complex absorption-time profiles.
  Clinical Drug Investigation™, December 01, 2006
• Neoadjuvant Treatment with Paclitaxel and Epirubicin in Breast Cancer Treatment with these two agents can make lumpectomy an option for more women who previously were not considered suitable candidates.
  Clinical Drug Investigation™, December 01, 2006
• Androgen Ablation with Brachytherapy for Prostate Cancer The findings from one institution offer some guidance on whether physicians should offer androgen ablation in these patients.
  Clinical Drug Investigation™, December 01, 2006
• Treatment of Chronic Bronchitis with Moxifloxacin or Macrolides One agent provided faster symptom relief and higher recovery rates than the other.
  Clinical Drug Investigation™, December 01, 2006
• Hypotensive Potential of Sildenafil and Tamsulosin During Orthostasis This case report demonstrates a need for caution when treating a patient simultaneously with these 2 drugs.
  Clinical Drug Investigation™, November 01, 2006
• A Taste Comparison of Liquid Colecalciferol (Vitamin D3) Preparations From a child's perspective, which tastes better: an oily preparation or an alcohol solution?
  Clinical Drug Investigation™, November 01, 2006
• Health-Economic Comparison of Paricalcitol, Calcitriol and Alfacalcidol This analysis suggested a clear benefit from the perspective of a third-party payer for one treatment over the others.
  Clinical Drug Investigation™, November 01, 2006
• Antiretroviral Therapy for Prevention of Mother-to-Child HIV Transmission Until better data are available, women and children who received single-dose nevirapine to prevent HIV transmission should be considered eligible for NNRTI-based regimens.
  Clinical Drug Investigation™, November 01, 2006
• Ritonavir/Saquinavir plus Rifampicin in HIV Patients with Tuberculosis Clinical benefits were evident with the studied drugs, but adverse events were the main limitation in treatment-naive patients.
  Clinical Drug Investigation™, October 25, 2006