Antiretroviral Therapy News

• Doravirine Effective in Treatment-naive Adults With HIV Doravirine, an investigational non-nucleoside reverse transcriptase inhibitor (NNRTI), is as effective as ritonavir-boosted darunavir, a protease inhibitor, in treatment-naive adults infected with HIV-1, according to results from the DRIVE-FORWARD trial.
  Reuters Health Information, April 2018
• Glecaprevir/pibrentasvir Treats Hepatitis C in HIV-coinfected Individuals The direct-acting antiviral (DAA) combination glecaprevir/pibrentasvir is effective for treating hepatitis C virus (HCV) infection in individuals coinfected with HIV-1, according to results from the non-randomized, open-label phase 3 EXPEDITION-2 trial.
  Reuters Health Information, April 2018
• Use of HIV-Prevention Drug Grows, but Lags Among Nonwhites Across the US, PrEP use is rising significantly. Blacks and Latinos, however, have been slow to embrace the medication even though HIV infection rates among them are much higher than among whites.
  Kaiser Health News, March 2018
• Tenofovir Alafenamide Plus Emtricitabine Effective, Safe in HIV In HIV patients, combination therapy with tenofovir alafenamide and emtricitabine is non-inferior to that of abacavir plus lamivudine, according to a manufacturer-sponsored trial.
  Reuters Health Information, March 2018
• CROIHIV Incidence Drops Below 2% in Vaginal Ring Follow-ups The vaginal ring was moderately protective against HIV in early studies. Now, interim data from two follow-up studies show that the incidence has dropped, but why this happened is a subject of debate.
  Medscape Medical News, March 2018
• CROI'Urgent Action' Needed to Prevent HIV in Black Americans New estimates show that half a million black Americans qualify for the HIV prevention pill, but only 1% of those have been prescribed PrEP.
  Medscape Medical News, March 2018
• Daily TB Therapy Best in HIV-positive Patients Daily anti-tuberculosis therapy works better than thrice-weekly dosing in reducing failures and acquired rifampicin resistance among HIV-infected patients with TB receiving antiretroviral therapy, according to a study from India.
  Reuters Health Information, March 2018
• Tenofovir Gel Less Effective in Women With Genital Inflammation Tenofovir gel is less effective in preventing HIV in women with genital inflammation, according to a post hoc analysis of data from the CAPRISA 004 study.
  Reuters Health Information, March 2018
• Pharmacokinetics of Tenofovir Vaginal Gel Differs by Age The pharmacokinetics of tenofovir vaginal gel differs between premenopausal and postmenopausal women, likely because of differences in the state of the cervicovaginal mucosa, researchers report.
  Reuters Health Information, February 2018
• Dolutegravir Pharmacokinetics Differ Between Pregnant and Postpartum Women The pharmacokinetics of dolutegravir, used to treat HIV infection, differ between pregnant women and postpartum women, but the differences are not likely to impair the drug's efficacy or safety.
  Reuters Health Information, February 2018
• U.S. FDA Approves Gilead's Biktarvy Triple HIV Drug The U.S. Food and Drug Administration on Wednesday approved Biktarvy, Gilead Sciences Inc's once-daily triple-combination tablet for treatment of HIV infection.
  Reuters Health Information, February 2018
• African-Americans Disproportionately Endangered by HIV/AIDS African-Americans are far more likely than other Americans to be infected with HIV but far less likely to get life-saving treatments that stop the virus’ spread, a new U.S. Centers for Disease Control and Prevention report finds.
  Reuters Health Information, February 2018
• HIV Infection a Risk Factor for Lung Dysfunction HIV infection is associated with reduced pulmonary function, according to findings from the Copenhagen Comorbidity in HIV infection (COCOMO) study group.
  Reuters Health Information, February 2018
• HIV Exposure or Infection in Utero May Portend Poorer Neurodevelopment
  Reuters Health Information, January 2018
• Latent HIV Reservoirs Resist Elimination by CD8-positive T Cells Treating latent HIV reservoirs with latency-reversing agents and autologous CD8+ T cells fails to eliminate replication-competent virus, researchers report.
  Reuters Health Information, January 2018
• Kaiser: Aetna Agrees to $17M Payout in HIV Privacy Breach Aetna settled a lawsuit for $17 million over a data breach that happened in the summer of 2017.
  Kaiser Health News, January 2018
• Dolutegravir-Rilpivirine Effective for Maintaining HIV Suppression The recently approved combination of dolutegravir and rilpivirine is effective for maintaining virological suppression in adults with HIV-1, according to results from the SWORD-1 and SWORD-2 noninferiority studies.
  Reuters Health Information, January 2018
• Guidelines Miss Many Young Black Men Who Need HIV PrEP Current U.S. guidelines lack sensitivity for identifying young black men who have sex with men who need HIV pre-exposure prophylaxis (PrEP), researchers report.
  Reuters Health Information, December 2017
• Prolonged Prophylaxis Prevents HIV Transmission During Breastfeeding Both maternal antiretroviral therapy (mART) and prolonged infant nevirapine prophylaxis (iNVP) safely help to prevent breastfeeding mothers from passing HIV-1 to their infants.
  Reuters Health Information, December 2017
• Statins Underused in Women With or Without HIV Only about a third of women in whom statins are indicated actually receive them, regardless of their HIV status, according to results from the Women's Interagency HIV Study (WIHS).
  Reuters Health Information, December 2017
• Many Young U.S. Men at High Risk for HIV Do Not Take Anti-HIV Pill Less than 4% of young adult men-who-have-sex-with-men (MSM) in the U.S. – a population at significant risk of contracting HIV infection – reported ever using the pill that protects them from the virus, in a recently published study.
  Reuters Health Information, December 2017