Antiretroviral Therapy News

• New Light Shed on HIV-1 Reservoir Reductions After Stem Cell Transplant Several factors underlie a profound reduction in the HIV-1 reservoir in patients who undergo allogeneic hematopoietic stem cell transplant (allo-HSCT) for hematologic disease, researchers report.
  Reuters Health Information, October 2018
• IDWeekEfavirenz in Pregnancy Tied to Neurologic Risk in Children The possibility for neurologic conditions in children more than doubles when the mother's antiretroviral regimen includes efavirenz, suggests a new study flagging the teratogenicity of the drug.
  Medscape Medical News, October 2018
• Desperate Border Crossings, as Venezuela Runs Short of HIV Drugs
  Reuters Health Information, October 2018
• Risk of Second Primary Cancer on the Rise in People With HIV
  Reuters Health Information, September 2018
• 'Beautiful, Long-Lived' HIV Suppression With Combo bNAbs A combination of two broadly neutralizing antibodies (bNAbs), infused together, led to HIV remission for 4 months, without the resistance that has been seen with a single bNAb, new research shows.
  Medscape Medical News, September 2018
• Pre-Exposure Prophylaxis Not Tied to Drug Resistance HIV-negative men who receive pre-exposure prophylaxis (PrEP) with tenofovir (TDF) and emtricitabine (FTC) do not develop resistance to these drugs, according to new findings from the IPERGAY ANRS trial.
  Reuters Health Information, September 2018
• New Single-pill Combo Effective Against HIV-1 A new fixed-dose combination of doravirine/lamivudine/tenofovir disoproxil fumarate (DOR/3TC/TDF) is noninferior to fixed-dose efavirenz/emtricitabine/TDF (EFV/FTC/TDF) in treatment-naive adults with HIV-1 infection, according to results from the DRIVE-AHEAD trial.
  Reuters Health Information, September 2018
• HIV Prevention Pill Reaching More People Who Need It More than one in nine people worldwide who might benefit from a daily pill to minimize their risk of getting HIV are now taking this medicine, a research review suggests.
  Reuters Health Information, September 2018
• Adding a Chest X-Ray to the WHO Four-Symptom Screening Rule May Help Detect TB in HIV Patients Adding a chest x-ray to the World Health Organization (WHO) four-symptom screening rule for tuberculosis (TB) may help detect more cases in people living with HIV while decreasing specificity, according to a new systematic review and meta-analysis.
  Reuters Health Information, September 2018
• Integrated Intervention Improves Care of HIV-Infected People Who Inject Drugs An intervention focusing on systems navigation, psychosocial counseling and antiretroviral therapy (ART) at any CD4 count improves outcomes among HIV-infected people who inject drugs (PWID), according to a feasibility and efficacy study.
  Reuters Health Information, September 2018
• Ibalizumab Reduces Viral Load in Multidrug-Resistant HIV-1 Ibalizumab significantly reduces viral load in patients with multidrug-resistant (MDR) HIV-1
  Reuters Health Information, August 2018
• HIV Viral Suppression Rates in US Nearly Tripled in Two Decades Rates of HIV viral suppression have nearly tripled among people living with HIV (PLWH) in the U.S. between 1997 and 2015, according to new findings.
  Reuters Health Information, August 2018
• HIV PrEP Use May Be a Gateway to Primary Care People who use HIV pre-exposure prophylaxis (PrEP) are also more likely to get routine care like flu shots and recommended screenings for common health problems, a U.S. study suggests.
  Reuters Health Information, August 2018
• In Utero Tenofovir Exposure May Not Affect Infant Bones A new pilot study suggests prenatal tenofovir exposure does not have a significant effect on infant bone mineral content (BMC) or bone mineral density (BMD).
  Reuters Health Information, August 2018
• DIY Tests for HIV Beat Stigma in Zimbabwe's Fight Against AIDS
  Reuters Health Information, August 2018
• AIDS 2018Paradoxes, Pitfalls Persist in HIV Remission Research Negative findings from the first randomized controlled trial of the kick-and-kill HIV cure approach highlight the limitations of current agents and raise questions about treatment interruption.
  Medscape Medical News, August 2018
• AIDS 2018Methadone Lowers HIV Transmission in Injection-Drug Users Medication-assisted addiction treatment plays an important role in HIV care, and a new study demonstrating this is being heralded as an inventive solution to address more than one problem at once.
  Medscape Medical News, July 2018
• AIDS 2018INSTI-based Two-Drug Antiretroviral Effective for New HIV The once-a-day antiretroviral regimen for patients new to treatment works and is safe, early results from the ongoing GEMINI trials suggest.
  Medscape Medical News, July 2018
• Protease Inhibitors in Patients With HIV, HF May Up CV Mortality Readmission for heart-failure decompensation and cardiovascular death are more likely for patients with HIV on antiretrovirals who are also taking protease inhibitors, suggests a single-center study.
  Medscape Medical News, July 2018
• AIDS 2018Women Tackle Tough Choice After Dolutegravir Birth Defects The antiretroviral taken at the time of conception has been linked to neural tube defects in babies, but a blanket ban of the drug for all women of childbearing age strikes some as discriminatory.
  Medscape Medical News, July 2018
• Event-Driven PrEP May Be an Alternative to Daily Dosing for Selected MSM Event-driven PrEP (Pre-Exposure Prophylaxis) may be a good alternative to taking PrEP daily, researchers report in a paper online June 29 in the Journal of Acquired Immune Deficiency Syndromes.
  Reuters Health Information, July 2018