Center of Excellence: Migraine: News & Perspective

• Migraine With Aura Linked to Increased Risk for AF Migraine with visual aura appears to increase the risk for incident atrial fibrillation (AF), a connection that may place this population at increased risk for subsequent ischemic stroke, new research suggests.
  Medscape Medical News, November 2018
• Erenumab for Migraine: Results Published Results for the phase 3 LIBERTY trial of the first approved migraine treatment targeting the CGRP receptor have been published.
  Medscape Medical News, October 2018
• Positive Topline Results for Migraine Drug in Two Safety Studies With positive efficacy data, two safety studies show that oral ubrogepant, a novel CGRP-targeting medication, is safe and well tolerated for treating acute migraine.
  Medscape Medical News, October 2018
• Alert FDA Greenlights Galcanezumab (Emgality) for Migraine Prevention On the heels of recent approvals for two other calcitonin gene-related peptide (CGRP) antagonists for the prevention of migraine in adults, the FDA has approved the anti-CGRP galcanezumab.
  FDA Approvals, September 2018
• CHMP Backs Galcanezumab for Migraine Prevention The EMA committee has recommended marketing authorization for a second CGRP antagonist for migraine prevention, following its first-in-class approval recommendation for erenumab in May.
  Medscape Medical News, September 2018
• Alert FDA Approves Fremanezumab (Ajovy) for Migraine Prevention The FDA has approved a second calcitonin-gene-related peptide antagonist for the prevention of migraine in adults.
  FDA Approvals, September 2018
• Headache Experts on What's Hot in Migraine Experts discuss the key findings from this year's American Headache Society meeting and promising research in migraine management.
  American Headache Society and Medscape, September 2018
• Headache MRI: What to Do With Incidental Findings Dr Randolph Evans reviews the prevalence and types of significant incidental findings on brain MRI for headaches.
  American Headache Society and Medscape, August 2018
• Migraine Prevention: Botox Wins, but Another Drug Enters the Ring   An open-label study prefers Botox over topiramate, but a new migraine prophylactic drug has joined the market, raising options as well as questions.
  Medscape Internal Medicine, July 2018
• AHS 2018Fremanezumab May Offer Prevention for Refractory Migraine A CGRP agent in development to prevent chronic migraine demonstrates efficacy in patients previously treated with topiramate or onabotulinumtoxinA.
  Medscape Medical News, July 2018
• AHS 2018Botox Tops Topiramate for Chronic Migraine Prevention Researchers compared tolerability, functional improvement, and more in a head-to-head comparison between onabotulinumtoxinA and topiramate for chronic migraine prevention.
  Medscape Medical News, July 2018
• AHS 2018Positive Phase 3 Results for Rimegepant in Acute Migraine The oral calcitonin gene-related peptide (CGRP) rimegepant performed well compared with placebo for treatment of a single acute migraine attack in a double-blind, randomized phase 3 trial.
  Medscape Medical News, July 2018
• AHS 2018Low-Dose Sumatriptan Auto-Injector for Migraine Better Tolerated How does a sumatriptan 3-mg auto-injector on the market compare in terms of tolerability and efficacy to treat an episodic migraine attack compared to 6-mg formulations?
  Medscape Medical News, July 2018
• AHS 2018Chronic Migraine, Not Treatment, Tied to Cognitive Impairment New research evaluates the possible role of comorbidities and topiramate treatment in cognitive impairment in patients with chronic migraine.
  Medscape Medical News, July 2018
• AHS 2018Erenumab Safe, Effective in Preventing Refractory Migraine A new monoclonal antibody is safe and effective in patients with migraine in whom several other preventive medications have failed.
  Medscape Medical News, July 2018
• AHS 2018Patients With Migraine More Likely to Suffer Poor Sleep Quality Patients with migraine are significantly more likely to report poorer-quality sleep than their counterparts with other headache types or people without headache. However, the underlying mechanism remains unclear.
  Medscape Medical News, June 2018
• Estrogen May Also Trigger Migraine in Men A Dutch study suggests estrogen may play a role in migraine in men, with higher levels making men more susceptible to migraines.
  Medscape Medical News, June 2018
• AAN 2018Eptinezumab Safe, Effective for Migraine Prevention A single dose of eptinezumab, which targets calcitonin gene-related peptide, provides rapid efficacy lasting up to 3 months in the prevention of chronic migraine, say PROMISE-2 investigators.
  Medscape Medical News, June 2018
• Looking Forward at Migraine Meds and 'Backwards' at Lumbar Punctures From the AAN 2018 Annual Meeting, Dr Deborah Friedman on the latest advances in migraine management, and more.
  American Headache Society and Medscape, June 2018
• Alert EU Panel Endorses Erenumab for Migraine Prevention An expert panel of the European Medicines Agency has recommended granting marketing authorization for erenumab, the first human monoclonal antibody for migraine prevention.
  International Approvals, June 2018