ION-I, ION-II, and ION-III

Trial Authors: Nezam Afdhal, MD (ION-I and ION-II) and Kris V. Kowdley, MD (ION-III)
Medscape Editors: Joanna Pangilinan, PharmD; Lauri Graham

June 25, 2014

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Contributor Information

Joanna Pangilinan, PharmD
Freelance writer

Disclosure: Joanna M. Pangilinan, PharmD, has disclosed no relevant financial relationships.

Lauri Graham
Editorial Director
Medscape Gastroenterology

References

  1. World Health Organization. Media centre. Hepatitis C. Fact sheet N° 164. Updated April 2014. http://www.who.int/mediacentre/factsheets/fs164/en/ Accessed June 9, 2014.
  2. Afdhal N, Zeuzem S, Kwo P, et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014;370:1889-1898.
  3. Mangia A, Marcellin P, Kwo P, et al. 0164 All oral fixed-dose combination sofosbuvir/ledipasvir with or without ribavirin for 12 or 24 weeks in treatment-naïve genotype 1 HCV-infected patients: the phase 3 ION-1 study. J Hepatol. 2014;60(Suppl):S523-S537.
  4. Afdhal N, Reddy R, Nelson DR, et al. Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. N Engl J Med. 2014;370:1483-1493.
  5. Afdhal N, Reddy RK, Pockros P, et al. 0109 All oral fixed-dose combination sofosbuvir/ledipasvir with or without ribavirin for 12 or 24 weeks in treatment-experienced genotype 1 HCV-infected patients: the phase 3 ION-2 study. J Hepatol. 2014;60(Suppl):S45-S66.
  6. Kowdley KV, Gordon SC, Reddy R, et al. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N Engl J Med. 2014;370:1879-1888.
  7. Kowdley KV, Gordon SC, Reddy KR, et al. Sofosbuvir/ledipasvir with and without ribavirin for 8 weeks compared to sofosbuvir/ledipasvir for 12 weeks in treatment-naïve non-cirrhotic genotype-1 HCV-infected patients: the phase 3 ION-3 study. Program and abstracts of Digestive Disease Week 2014; May 3-6, 2014; Chicago, Illinois. Abstract 764.
  8. Kowdley KV, Stuart GC, Reddy RK, et al. 056 Sofosbuvir/ledipasvir with and without ribavirin for 8 weeks compared to sofosbuvir/ledipasvir for 12 weeks in treatment-naïve non-cirrhotic genotype-1 HCV-infected patients: the phase 3 ION-3 study. J Hepatol. 2014;60(Suppl):S23-S44.
  9. Tucker ME. Once-daily pill cures most hepatitis C genotype 1 patients. http://www.medscape.com/viewarticle/823549 Accessed June 9, 2014.