Which medications in the drug class Anthelmintics are used in the treatment of Dientamoeba Fragilis Infection?

Updated: Jul 31, 2018
  • Author: Maria A Garcia Fernandez, MD; Chief Editor: Russell W Steele, MD  more...
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Parasite biochemical pathways are different from the human host; thus, toxicity is directed to the parasite, egg, or larvae. Mechanism of action varies within the drug class. Antiparasitic actions may include the following:

1. Inhibition of microtubules, causing irreversible block of glucose uptake

2. Tubulin polymerization inhibition

3. Depolarizing neuromuscular blockade

4. Cholinesterase inhibition

5. Increased cell membrane permeability, resulting in intracellular calcium loss

6. Vacuolization of the schistosome tegument

7. Increased cell membrane permeability to chloride ions via chloride channels alteration

Metronidazole (Flagyl)

Imidazole ring-based antibiotic active against various anaerobic bacteria and protozoa.

Tetracycline (Sumycin)

Inhibits bacterial protein synthesis by binding with 30S and, possibly, 50S ribosomal subunits.

Iodoquinol (Yodoxin)

Amebicide used in treatment of D fragilis.

Paromomycin (Humatin)

Amebicidal and antibacterial aminoglycoside obtained from strain of Streptomyces rimosus; active in intestinal amebiasis.

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