What is an effective treatment option for noninfectious, therapy-resistant otitis externa (OE)?

Updated: Mar 09, 2020
  • Author: Ariel A Waitzman, MD, FRCSC; Chief Editor: Ravindhra G Elluru, MD, PhD  more...
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In the setting of chronic, noninfectious, therapy-resistant OE, a prospective study by Caffier et al demonstrated that daily use of 0.1% tacrolimus cream (administered via an ear wick [see below] that was changed every second to third day) resulted in high rates of resolution (46% through 1-2 years of follow-up) after 9-12 days of therapy. [24] The study also demonstrated longer periods of symptom-free intervals for those who experienced a recurrence.

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