Which combination topical preparation is no longer recommended to treat otitis externa (OE), and why?

Updated: Mar 09, 2020
  • Author: Ariel A Waitzman, MD, FRCSC; Chief Editor: Ravindhra G Elluru, MD, PhD  more...
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An aminoglycoside combined with a second antibiotic and a topical steroid (eg, neomycin−polymyxin B−hydrocortisone) used to be the most commonly prescribed topical preparation; however, the neomycin component led to hypersensitivity reactions and ototoxicity in some patients.

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