Which medications in the drug class Corticosteroids, Intranasal are used in the treatment of Pediatric Nasal Polyps?

Updated: Oct 25, 2019
  • Author: John E McClay, MD; Chief Editor: Ravindhra G Elluru, MD, PhD  more...
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Answer

Corticosteroids, Intranasal

These agents induce a nonspecific anti-inflammatory response that should theoretically reduce the size of polyps and prevent regrowth when continuously used. Available nasal steroid sprays appear to be similarly effective and relatively safe for both short-term and long-term use.

Mometasone, intranasal (Nasonex)

Nasal spray; demonstrated no mineralocorticoid, androgenic, antiandrogenic, or estrogenic activity in preclinical trials. Studies concerning bioavailability are established; should be considered first-line therapy for pediatric patients. Not systemically absorbed like other nasal steroids (eg, beclomethasone). 

Fluticasone intranasal (Children's Flonase Allergy Relief, ClariSpray, Flonase Allergy Relief)

Topical nasal steroid. Has extremely potent vasoconstrictive and anti-inflammatory activity. Has a weak hypothalamic-pituitary-adrenocortical axis inhibitory potency when applied topically. Studies concerning bioavailability are established; should be considered first line when treating pediatric patients. Not systemically absorbed like other nasal steroids (ie, beclomethasone).

Nasal drying, epistaxis, and, in long-term use, septal perforation has been reported. Advise patients to administer spray toward lateral nasal wall, avoiding irritation to septum or having drug run down back of pharynx.

Budesonide intranasal (Rhinocort Allergy)

Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability.

Triamcinolone, intranasal (Nasacort Allergy 24HR)

Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability.

Beclomethasone, intranasal (Beconase AQ, QNASL)

Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability. Delivers 42 mcg/actuation.


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