Which polyposis syndromes are associated with colorectal cancer?

Updated: Jun 06, 2020
  • Author: Jaime Shalkow, MD, FACS; Chief Editor: Cameron K Tebbi, MD  more...
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Answer

Answer

Syndromes associated with CRC include the following:

  • Gardner syndrome - Polyposis, osteomas, and multiple sebaceous cysts

  • Turcot syndrome - Polyposis and brain tumors (gliomas, ependymomas)

  • Peutz-Jeghers syndrome - Colonic polyposis, ovarian tumors, and mucocutaneous pigmentation of lips, oral mucosa, and perioral region

  • Cronkhite-Canada syndrome - GI polyposis, skin hyperpigmentation, alopecia, and nail changes

  • Osler-Weber-Rendu syndrome - Juvenile polyps and hepatic telangiectasia

  • Oldfield syndrome - Polyposis and multiple sebaceous cysts

  • Bloom syndrome - Growth retardation, accelerated aging, immune deficiency, and malignant tumors

  • Cowden syndrome - Hamartomas, GI polyps, breast, thyroid, and GI cancer

  • Ruvalcaba-Myhre-Smith syndrome - Microcephaly and juvenile polyposis in males; no cancer

  • Serrated polyposis syndrome

  • MutYH-associated polyposis syndrome


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