What are the T-cell-based immunotherapeutic targets in pediatric oncology?

Updated: Mar 20, 2018
  • Author: Crystal L Mackall, MD; Chief Editor: Jennifer Reikes Willert, MD  more...
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Answer

Perhaps the most effective form of immunotherapy of cancer is the graft-versus-leukemia effect mediated by allogeneic T cells after bone marrow transplantation for leukemia. [40] The ability of transferred T-cells to eradicate leukemia highly depends on the type of leukemia, the degree of tumor burden, and the rate of disease progression.

Careful clinical trials are necessary to target tumor histologies and tumor burdens most receptive to immune-based therapies, and creative combination strategies are likely to be needed to enhance the effectiveness of T cell–mediated antitumor effects in most clinical settings.


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