How do MDSCs affect immunotherapeutic targeting in pediatric oncology?

Updated: Mar 20, 2018
  • Author: Crystal L Mackall, MD; Chief Editor: Jennifer Reikes Willert, MD  more...
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Answer

The role of myeloid-derived suppressor cells (MDSCs) as an important component of the immunosuppressive microenvironment of tumors is becoming better appreciated. Tumor growth results in expansion of this subset, causing a reduction in arginine levels and a subsequent increase in nitric oxide (NO) in tumors, which inhibits T-cell activation and antigen-specific responses. Therapies that inhibit cyclooxygenase-2 enzyme activity, inhibit MDSC function, or cause MDSC differentiation (eg, all-trans retinoic acid) are being explored in preclinical models. [39]


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